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United States

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製品番号: HY-143334

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Antifungal agent 84

Antibacterial agent 84 is an antifungal compound. Antibacterial agent 84 inhibits candidiasis in a CNB1-dependent way. Antibacterial agent 84 inhibits the C. albicans biofilm's viability.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2901064-07-9
分子式: C₂₅H₁₉BrClFN₆O
分子量:553.81

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Antifungal agent 84 構造式

CAS 番号: 2901064-07-9

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Antibacterial agent 84 is an antifungal compound. Antibacterial agent 84 inhibits candidiasis in a CNB1-dependent way. Antibacterial agent 84 inhibits the C. albicans biofilm's viability^[1].

体外実験

Antibacterial agent 84 (compound 6d) (1-16 μg/mL) inhibits human pathogen C. albicans SC5314 growth^[1].
Antibacterial agent 84 (16 μg/mL, 18 h) induces endogenous reactive oxygen species (ROS) production in C. albicans in a CNB1-dependent way^[1].
Antibacterial agent 84 (16 μg/mL, 18 h) is cytotoxic against lysosomal membrane permeabilization in C. albicans^[1].
Antibacterial agent 84 (16 μg/mL, 18 h) induces C. albicans phagocytosis by macrophages^[1].
Antibacterial agent 84 (0.06-32 μg/mL) inhibits ergosterol synthesis in in cultures of C. albicans and C. tropicalis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

C. albicans (SC5314)
Concentration:

1-16 μg/mL
Incubation Time:

18 or 48 h
Result:

Inhibited C. albicans SC5314 growth by nearly 100%.

体内実験

Antibacterial agent 84 (16 μg/mL, injected into the right pro-leg) aids in the clearance of fungi 1 h post-infection in G. mellonella larvae infected by C. albicans^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

G. mellonella larvae infected by C. albicans^[1]
Dosage:

16 μg/mL
Administration:

Injected into the right pro-leg of the last instar larvae.
Result:

Realized the clearance of fungi 1 h post-infection.

Related Protocols :

化学情報

CAS 番号 2901064-07-9
分子量 553.81
分子式 C₂₅H₁₉BrClFN₆O
SMILES

ClC(C=CC=C1)=C1C2=NN(N=N2)CCCN3C(CN=C(C4=C3C=CC(F)=C4)C5=C(C=CC=C5)Br)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (274 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Staniszewska M, et al. Tetrazole derivatives bearing benzodiazepine moiety-synthesis and action mode against virulence of Candida albicans. Eur J Med Chem. 2022 Feb 15;230:114060. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Minimum order quantity

100 mg

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