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Cat. No.: HY-143334

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Antifungal agent 84

Antibacterial agent 84 is an antifungal compound. Antibacterial agent 84 inhibits candidiasis in a CNB1-dependent way. Antibacterial agent 84 inhibits the C. albicans biofilm's viability.

For research use only. We do not sell to patients.

CAS No.: 2901064-07-9
Formula: C₂₅H₁₉BrClFN₆O
Molecular Weight:553.81

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Antifungal agent 84 Chemical Structure

CAS No.: 2901064-07-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Antibacterial agent 84 is an antifungal compound. Antibacterial agent 84 inhibits candidiasis in a CNB1-dependent way. Antibacterial agent 84 inhibits the C. albicans biofilm's viability^[1].

In Vitro

Antibacterial agent 84 (compound 6d) (1-16 μg/mL) inhibits human pathogen C. albicans SC5314 growth^[1].
Antibacterial agent 84 (16 μg/mL, 18 h) induces endogenous reactive oxygen species (ROS) production in C. albicans in a CNB1-dependent way^[1].
Antibacterial agent 84 (16 μg/mL, 18 h) is cytotoxic against lysosomal membrane permeabilization in C. albicans^[1].
Antibacterial agent 84 (16 μg/mL, 18 h) induces C. albicans phagocytosis by macrophages^[1].
Antibacterial agent 84 (0.06-32 μg/mL) inhibits ergosterol synthesis in in cultures of C. albicans and C. tropicalis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

C. albicans (SC5314)
Concentration:

1-16 μg/mL
Incubation Time:

18 or 48 h
Result:

Inhibited C. albicans SC5314 growth by nearly 100%.

In Vivo

Antibacterial agent 84 (16 μg/mL, injected into the right pro-leg) aids in the clearance of fungi 1 h post-infection in G. mellonella larvae infected by C. albicans^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

G. mellonella larvae infected by C. albicans^[1]
Dosage:

16 μg/mL
Administration:

Injected into the right pro-leg of the last instar larvae.
Result:

Realized the clearance of fungi 1 h post-infection.

Chemical Information

CAS No. 2901064-07-9
Molecular Weight 553.81
Formula C₂₅H₁₉BrClFN₆O
SMILES

ClC(C=CC=C1)=C1C2=NN(N=N2)CCCN3C(CN=C(C4=C3C=CC(F)=C4)C5=C(C=CC=C5)Br)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Staniszewska M, et al. Tetrazole derivatives bearing benzodiazepine moiety-synthesis and action mode against virulence of Candida albicans. Eur J Med Chem. 2022 Feb 15;230:114060. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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