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Cat. No.: HY-163381

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Antiproliferative agent-48

Antiproliferative agent-48 (compound PC-A1) shows selective antiproliferative activity against triple-negative breast cancer (TNBC) cells.

For research use only. We do not sell to patients.

CAS No.: 1621594-62-4
Formula: C₁₄H₁₇BrO₃
Molecular Weight:313.19

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Antiproliferative agent-48 Chemical Structure

CAS No.: 1621594-62-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Antiproliferative agent-48 (compound PC-A1) shows selective antiproliferative activity against triple-negative breast cancer (TNBC) cells^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	19 μM Compound: 1; PC-A	Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 72 hrs by sulforhodamine B assay Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 72 hrs by sulforhodamine B assay	[PMID: 38438305]
KB	IC₅₀	15 μM Compound: 1; PC-A	Antiproliferative activity against human KB cells assessed as cell growth inhibition incubated for 72 hrs by sulforhodamine B assay Antiproliferative activity against human KB cells assessed as cell growth inhibition incubated for 72 hrs by sulforhodamine B assay	[PMID: 38438305]
MCF7	IC₅₀	13 μM Compound: 1; PC-A	Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by sulforhodamine B assay Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by sulforhodamine B assay	[PMID: 38438305]
MDA-MB-231	IC₅₀	5.2 μM Compound: 1; PC-A	Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by sulforhodamine B assay Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by sulforhodamine B assay	[PMID: 38438305]

In Vitro

Antiproliferative agent-48 (5-50 μM) inhibits proliferations against cancer cells MDA-MB-231 (TNBC), MCF-7, A549, KB (HeLa derivative) and KB-VIN with IC₅₀s of 5.4, 18, 19, 15 and 19 μM, respectively^[1].
Antiproliferative agent-48 (5-50 μM) arrests the cell cycle at G2/M phase^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

MDA-MB-231, MCF-7, A549, KB and KB-VIN
Concentration:

5-50 μM
Incubation Time:

72 h
Result:

Inhibited proliferations in micromolar levels.

Cell Cycle Analysis^[1]

Cell Line:

MDA-MB-231
Concentration:

5-50 μM
Incubation Time:

24 h
Result:

Arrested the cell cycle at G2/M phase.

Chemical Information

CAS No. 1621594-62-4
Molecular Weight 313.19
Formula C₁₄H₁₇BrO₃
SMILES

O[C@H]1C=C(Br)C2=CC(O)=C(C(C)=O)C[C@]2(C)[C@H]1C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Maeda S, et al., Total Synthesis of a TNBC-Selective Cytotoxic Bromo Nor-eremophilane, PC-A, and Its Preliminary Structure-Activity Relationships. J Nat Prod. 2024 Mar 4.

[2]. Maeda S, et al., Total Synthesis of a TNBC-Selective Cytotoxic Bromo Nor-eremophilane, PC-A, and Its Preliminary Structure-Activity Relationships. J Nat Prod. 2024 Mar 4. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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