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Cat. No.: HY-151957

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Antitubercular agent 34

Antitubercular agent 34 (compound 42g) is an antitubercular agent. Antitubercular agent 34 inhibits the growth of Mtb_H37Rv with a MIC₉₀ value of 1.25 μg/mL with the ability of escaping metabolic degradation by human liver microsomes. Antitubercular agent 34 can be used for the research of tuberculosis.

For research use only. We do not sell to patients.

CAS No.: 2883173-23-5
Formula: C₁₉H₁₄N₄O₂S
Molecular Weight:362.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Antitubercular agent 34 Chemical Structure

CAS No.: 2883173-23-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
THP-1	IC₅₀	11.9 μg/mL Compound: 42g	Cytotoxicity against human THP-1 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay Cytotoxicity against human THP-1 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay	[PMID: 36399878]

In Vitro

Antitubercular agent 34 (0-20 μg/mL; 3-4 d) shows inhibitory effect to Mtb_H37Rv with a MIC₉₀ value of 1.25 μg/mL^[1].
Antitubercular agent 34 (0-100 μM; 3 d) shows inhibitory effect to human monocytes THP-I cell line^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

Human monocytes THP-I cell line
Concentration:

1, 10, 50 and 100 μM
Incubation Time:

72 hours
Result:

Inhibited the growth of THP-I cells with an IC₅₀ value of 11.9 μg/mL.

Chemical Information

CAS No. 2883173-23-5
Molecular Weight 362.41
Formula C₁₉H₁₄N₄O₂S
SMILES

O=C(C1=NOC(C2=CSC(NC3=CC=CC=C3)=N2)=C1)NC4=CC=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Girardini M, et al. Expanding the knowledge around antitubercular 5-(2-aminothiazol-4-yl)isoxazole-3-carboxamides: Hit-to-lead optimization and release of a novel antitubercular chemotype via scaffold derivatization. Eur J Med Chem. 2023 Jan 5;245(Pt 2):114916. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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