Aplithianines A
Aplithianines A is a potent inhibitor against J-PKAcα with an IC50 of 1 μM , and inhibits wild-type PKA with an IC50 of 84 nM. Aplithianines A inhibits J-PKAcα catalytic activity by competitively binding to the ATP pocket.
For research use only. We do not sell to patients.
- CAS No.: 3027425-38-0
- Formula: C13H13N7S
- Molecular Weight:299.35
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
1 μM (J-PKAcα)[1]
Chemical Information
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CAS No. 3027425-38-0
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Molecular Weight 299.35
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Formula C13H13N7S
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SMILES
CN1C=NC=C1C(SCC2)=CN2C3=NC=NC4=C3N=CN4
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Structure Classification
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Initial Source
Aplidium sp.
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Aplithianines A Related Classifications
HY-N12399 Related Classifications
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