Araliadiol

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Araliadiol is a polyacetylenic compound isolated from the leaves of Aralia cordata Thunb. Araliadiol inhibits MCF-7 cells growth with an IC₅₀ value of 6.41 µg/mL.

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Araliadiol Chemical Structure

CAS No. : 1354638-93-9

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5 mg	Get quote	Estimated Time of Arrival: December 31
10 mg	Get quote	Estimated Time of Arrival: December 31
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Description

Araliadiol is a polyacetylenic compound isolated from the leaves of Aralia cordata Thunb. Araliadiol inhibits MCF-7 cells growth with an IC₅₀ value of 6.41 µg/mL^[1].

IC₅₀ & Target

IC50: 6.41 µg/mL (MCF-7 cells growth)^[1]

In Vitro

Araliadiol (20-80 µM; 0-48 hours; MCF-7 cells) treatment inhibits cell cycle progression of MCF-7 at the G1-S transition^[1].
Araliadiol (20-80 µM; 0-48 hours; MCF-7 cells) treatment inhibits phosphorylation of retinoblastoma protein (Rb) in MCF-7 cells, accompanies by a decrease in the levels of cyclin D₃ and cdk4 and an increase in the expression of p21 (WAF-1/Cip1)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:	MCF-7 cells
Concentration:	20 µM, 40 µM, and 80 µM
Incubation Time:	0 hour, 6 hours, 12 hours, 18 hours, 24 hours, and 48 hours
Result:	The proportion of cells in the G1 phase of the cell cycle increased in a dose-dependent manner (from 54.7 % to 72.0 %).

Western Blot Analysis^[1]

Cell Line:	MCF-7 cells
Concentration:	20 µM, 40 µM, and 80 µM
Incubation Time:	48 hours
Result:	Phosphorylation of retinoblastoma protein (Rb) in MCF-7 cells was inhibited, accompanied by a decrease in the levels of cyclin D₃ and cyclin-dependent kinase 4 (cdk4) and an increase in the expression of p21 (WAF-1/Cip1).

Molecular Weight

232.32

Formula

C₁₅H₂₀O₂

CAS No.

1354638-93-9

SMILES

C=C[C@H](O)C#CC#C[C@H](O)/C=C\CCCCC

Structure Classification

Others

Initial Source

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Cheng WL, et al. Inhibitory effect of human breast cancer cell proliferation via p21-mediated G1 cell cycle arrest by araliadiol isolated from Aralia cordata Thunb. Planta Med. 2011 Jan;77(2):164-8. [Content Brief]

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Araliadiol1354638-93-9OthersPolyacetyleniccytotoxicityG1-phasecdk4cyclin-D3Inhibitorinhibitorinhibit

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