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Araliadiol 

Cat. No.: HY-N2887
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Araliadiol is a polyacetylenic compound isolated from the leaves of Aralia cordata Thunb. Araliadiol inhibits MCF-7 cells growth with an IC50 value of 6.41 µg/mL.

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Araliadiol Chemical Structure

Araliadiol Chemical Structure

CAS No. : 1354638-93-9

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Description

Araliadiol is a polyacetylenic compound isolated from the leaves of Aralia cordata Thunb. Araliadiol inhibits MCF-7 cells growth with an IC50 value of 6.41 µg/mL[1].

IC50 & Target

IC50: 6.41 µg/mL (MCF-7 cells growth)[1]

In Vitro

Araliadiol (20-80 µM; 0-48 hours; MCF-7 cells) treatment inhibits cell cycle progression of MCF-7 at the G1-S transition[1].
Araliadiol (20-80 µM; 0-48 hours; MCF-7 cells) treatment inhibits phosphorylation of retinoblastoma protein (Rb) in MCF-7 cells, accompanies by a decrease in the levels of cyclin D3 and cdk4 and an increase in the expression of p21 (WAF-1/Cip1)[1].

Cell Cycle Analysis[1]

Cell Line: MCF-7 cells
Concentration: 20 µM, 40 µM, and 80 µM
Incubation Time: 0 hour, 6 hours, 12 hours, 18 hours, 24 hours, and 48 hours
Result: The proportion of cells in the G1 phase of the cell cycle increased in a dose-dependent manner (from 54.7 % to 72.0 %).

Western Blot Analysis[1]

Cell Line: MCF-7 cells
Concentration: 20 µM, 40 µM, and 80 µM
Incubation Time: 48 hours
Result: Phosphorylation of retinoblastoma protein (Rb) in MCF-7 cells was inhibited, accompanied by a decrease in the levels of cyclin D3 and cyclin-dependent kinase 4 (cdk4) and an increase in the expression of p21 (WAF-1/Cip1).
Molecular Weight

232.32

Formula

C₁₅H₂₀O₂

CAS No.

1354638-93-9

SMILES

C=C[[email protected]](O)C#CC#C[[email protected]](O)/C=C\CCCCC

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

AraliadiolOthersPolyacetyleniccytotoxicityG1-phasecdk4cyclin-D3Inhibitorinhibitorinhibit

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