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Cat. No.: HY-124927

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ARN14988

Name: ARN14988
Brand: MedChemExpress
SKU: HY-124927
Price: 103.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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ARN14988 is a potent inhibitor of acid ceramidase (ACDase) (IC₅₀=12.8 nM for the human enzyme).

For research use only. We do not sell to patients.

Purity : 99.9%
CAS No.: 1502027-70-4
Formula: C₁₆H₂₄ClN₃O₅
Molecular Weight:373.83

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

ARN14988 Chemical Structure

CAS No.: 1502027-70-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

HY-116392H
D,L-erythro-PDMP hydrochloride

PDMP Erythro Isomer

Biological Activity

Description

ARN14988 is a potent inhibitor of acid ceramidase (ACDase) (IC₅₀=12.8 nM for the human enzyme)^[1].

Chemical Information

CAS No. 1502027-70-4
Appearance Solid
Molecular Weight 373.83
Formula C₁₆H₂₄ClN₃O₅
Color White to off-white
SMILES

O=C(N(C1=O)C(C(Cl)=CN1C(NCCCCCC)=O)=O)OCC(C)C
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Realini N, et al. Acid Ceramidase in Melanoma: EXPRESSION, LOCALIZATION, AND EFFECTS OF PHARMACOLOGICAL INHIBITION. J Biol Chem. 2016 Jan 29;291(5):2422-34. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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