AT-076
AT-076 is an opioid pan antagonist at nociception, kappa, mu, and delta opioid receptors, with Ki values of 1.75 nM (NOP), 1.67 nM (MOP), 1.14 nM (KOP) and 19.6 nM (DOP), respectively.
For research use only. We do not sell to patients.
- CAS No.: 1657028-64-2
- Formula: C26H35N3O3
- Molecular Weight:437.57
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Opioid Receptor Isoforms
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Biological Activity
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NOP Receptor/ORL1 1.75 nM (IC50) |
μ Opioid Receptor/MOR 1.67 nM (IC50) |
κ Opioid Receptor/KOR 1.14 nM (IC50) |
δ Opioid Receptor/DOR 19.6 nM (IC50) |
Chemical Information
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CAS No. 1657028-64-2
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Molecular Weight 437.57
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Formula C26H35N3O3
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SMILES
OC1=CC=CC(C(CC2)CCN2C[C@H](C(C)C)NC([C@H]3CC4=CC=C(O)C=C4CN3)=O)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Nurulain T Zaveri, et al. Discovery of the first small-molecule opioid pan antagonist with nanomolar affinity at mu, delta, kappa, and nociceptin opioid receptors. ACS Chem Neurosci. 2015 Apr 15;6(4):646-57. [Content Brief]
[2]. V Blair Journigan, et al. Probing ligand recognition of the opioid pan antagonist AT-076 at nociceptin, kappa, mu, and delta opioid receptors through structure-activity relationships. Sci Rep. 2017 Oct 16;7(1):13255. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AT-076 Related Classifications
HY-106732 Related Classifications
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