3-Hydroxyterphenyllin
3-Hydroxyterphenyllin is a metabolite of Aspergillus candidus.3-Hydroxyterphenyllin suppresses proliferation and causes cytotoxicity against A2780/CP70 and OVCAR-3 cells. 3-Hydroxyterphenyllin induces S phase arrest and apoptosis. 3-Hydroxyterphenyllin has the potential for the research of ovarian cancer.
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- CAS. Nr.: 66163-76-6
- Formel: C20H18O6
- Molecular Weight:354.35
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
34.68 μM
Compound: 11
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Cytotoxicity against human A549 cells by SRB assay
Cytotoxicity against human A549 cells by SRB assay
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[PMID: 21486068] |
| HL-60 | IC50 |
9.86 μM
Compound: 11
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Cytotoxicity against human HL60 cells by MTT assay
Cytotoxicity against human HL60 cells by MTT assay
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[PMID: 21486068] |
| MDA-MB-435 | IC50 |
<20 μM
Compound: 3
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Cytotoxicity against human MDA-MB-435 cells
Cytotoxicity against human MDA-MB-435 cells
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[PMID: 29407953] |
| P388 | IC50 |
28.06 μM
Compound: 11
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Cytotoxicity against mouse P388 cells by MTT assay
Cytotoxicity against mouse P388 cells by MTT assay
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[PMID: 21486068] |
Chemical Information
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CAS. Nr. 66163-76-6
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Molecular Weight 354.35
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Formel C20H18O6
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SMILES
OC1=CC=C(C2=CC(OC)=C(C3=CC=C(C(O)=C3)O)C(O)=C2OC)C=C1
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Synonyms
NSC 299113
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Structure Classification
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Initial Source
Aspergillus candidus LINK
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Kurobane I, et al. 3-Hydroxyterphenyllin, a new metabolite of Aspergillus candidus. Structure elucidation by H and C nuclear magnetic resonance spectroscopy. J Antibiot (Tokyo). 1979;32(6):559-564. [Content Brief]
[2]. Wang Y, et al. 3-Hydroxyterphenyllin, a natural fungal metabolite, induces apoptosis and S phase arrest in human ovarian carcinoma cells. Int J Oncol. 2017;50(4):1392-1402. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
3-Hydroxyterphenyllin Related Classifications
HY-N10268 Related Classifications
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