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Art. -Nr.: HY-N1892

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4'-Demethyleucomin

(Synonyms: O-Demethyleucomin)

4'-Demethyleucomin (O-Demethyleucomin) is a Sesquiterpenoids product that can be isolated from the herbs of Polygonum hydropiper.

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CAS. Nr.: 34818-83-2
Formel: C₁₆H₁₂O₅
Molecular Weight:284.26

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (239 KB)

4'-Demethyleucomin Chemical Structure

CAS. Nr.: 34818-83-2

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Biologische Aktivität

Beschreibung

4'-Demethyleucomin (O-Demethyleucomin) is a Sesquiterpenoids product that can be isolated from the herbs of Polygonum hydropiper^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
3T3-L1	IC₅₀	>100 μM Compound: 9	Antiadipogenic activity against mouse 3T3L1 cells assessed as inhibition of differentiation after 7 days by oil-red O staining Antiadipogenic activity against mouse 3T3L1 cells assessed as inhibition of differentiation after 7 days by oil-red O staining	[PMID: 19757853]
ARPE-19	GI₅₀	>100 μM Compound: 34	Antiproliferative activity against human ARPE19 assessed as reduction in cell number incubated for 44 hrs by alamar blue based fluorescence assay Antiproliferative activity against human ARPE19 assessed as reduction in cell number incubated for 44 hrs by alamar blue based fluorescence assay	[PMID: 30951308]
BTI-TN-5B1-4	IC₅₀	11.46 μM Compound: 1h	Inhibition of human recombinant MAO-A expressed in baculovirus infected BTI-TN-5B1-4 insect sells assessed as hydrogen peroxide production by fluorimetric method Inhibition of human recombinant MAO-A expressed in baculovirus infected BTI-TN-5B1-4 insect sells assessed as hydrogen peroxide production by fluorimetric method	[PMID: 21405131]
BTI-TN-5B1-4	IC₅₀	8.61 nM Compound: 1h	Inhibition of human recombinant MAO-B expressed in baculovirus infected BTI-TN-5B1-4 insect sells assessed as hydrogen peroxide production by fluorimetric method Inhibition of human recombinant MAO-B expressed in baculovirus infected BTI-TN-5B1-4 insect sells assessed as hydrogen peroxide production by fluorimetric method	[PMID: 21405131]
HT-29	IC₅₀	>20 μM Compound: 11	Cytotoxicity against human HT-29 cells assessed as reduction in cell growth incubated for 72 hrs Cytotoxicity against human HT-29 cells assessed as reduction in cell growth incubated for 72 hrs	[PMID: 26147490]
MDA-MB-435	IC₅₀	>20 μM Compound: 11	Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell growth incubated for 72 hrs Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell growth incubated for 72 hrs	[PMID: 26147490]
Y79	GI₅₀	>100 μM Compound: 34	Cytotoxicity against human Y79 cells assessed as reduction in cell number incubated for 44 hrs by alamar blue based fluorescence assay Cytotoxicity against human Y79 cells assessed as reduction in cell number incubated for 44 hrs by alamar blue based fluorescence assay	[PMID: 30951308]

Chemical Information

CAS. Nr. 34818-83-2
Molecular Weight 284.26
Formel C₁₆H₁₂O₅
SMILES

O=C1/C(COC2=CC(O)=CC(O)=C12)=C/C3=CC=C(O)C=C3
Synonyms

O-Demethyleucomin
Structure Classification
- Flavonoids
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.