CPDA
Based on 1 publication(s) in Google Scholar
CPDA is a novel potent SH2 domain-containing inositol phosphatase 2 (SHIP2) inhibitor.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 98.65%
- CAS. Nr.: 1415834-63-7
- Formel: C20H15ClF2N2O2
- Molecular Weight:388.80
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) CPDA
More
Biologische Aktivität
Beschreibung
IC50 & Target
SHIP2
In Vitro
CPDA enhances insulin signaling.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 1415834-63-7
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Appearance Solid
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Molecular Weight 388.80
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Formel C20H15ClF2N2O2
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Color Light yellow to yellow
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SMILES
O=C(NC1=NC=CC(OCC2=CC=C(Cl)C=C2)=C1)CC3=C(F)C=CC=C3F
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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Biochem Biophys Res Commun
2026 Jul 9:821:153883. PMID: 42097047
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : ≥ 50 mg/mL (128.60 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.43 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (269 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5720 mL | 12.8601 mL | 25.7202 mL | 64.3004 mL |
| 5 mM | 0.5144 mL | 2.5720 mL | 5.1440 mL | 12.8601 mL | |
| 10 mM | 0.2572 mL | 1.2860 mL | 2.5720 mL | 6.4300 mL | |
| 15 mM | 0.1715 mL | 0.8573 mL | 1.7147 mL | 4.2867 mL | |
| 20 mM | 0.1286 mL | 0.6430 mL | 1.2860 mL | 3.2150 mL | |
| 25 mM | 0.1029 mL | 0.5144 mL | 1.0288 mL | 2.5720 mL | |
| 30 mM | 0.0857 mL | 0.4287 mL | 0.8573 mL | 2.1433 mL | |
| 40 mM | 0.0643 mL | 0.3215 mL | 0.6430 mL | 1.6075 mL | |
| 50 mM | 0.0514 mL | 0.2572 mL | 0.5144 mL | 1.2860 mL | |
| 60 mM | 0.0429 mL | 0.2143 mL | 0.4287 mL | 1.0717 mL | |
| 80 mM | 0.0322 mL | 0.1608 mL | 0.3215 mL | 0.8038 mL | |
| 100 mM | 0.0257 mL | 0.1286 mL | 0.2572 mL | 0.6430 mL |
CPDA Related Classifications
HY-18685 Related Classifications
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