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Art. -Nr.: HY-B1474

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Alexidine

Name: Alexidine
Brand: MedChemExpress
SKU: HY-B1474
Availability: PreOrder

5 Cited Publications

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Based on 5 publication(s) in Google Scholar

Alexidine, a bis-biguanide, exhibits antifungal and antibiofilm activity against a diverse range of fungal pathogens. Alexidine is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis.

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CAS. Nr.: 22573-93-9
Formel: C₂₆H₅₆N₁₀
Molecular Weight:508.79

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Alexidine Chemical Structure

CAS. Nr.: 22573-93-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Publications (5)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Alexidine (10 µM, 24 hours) treatment can decimate the biofilm community^[1].
Alexidine (0-60 μg/ml, 24 hours) treatment can kill HUVECs and lung A549 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

C. albicans, C. auris, A. fumigatus
Concentration:

10 µM
Incubation Time:

24 hours
Result:

Could significantly kill 80% of mature biofilm community.

Cell Viability Assay^[1]

Cell Line:

HUVECs, lung A549 cells
Concentration:

0-60 μg/ml
Incubation Time:

24 hours
Result:

resulted in 50% killing of HUVECs and lung A549 cells ( CC₅₀ > 7.37 μg/ml ).

In Vivo

Alexidine (Jugular vein-catheterized; 48 hours; 3 µg/ml; once) can decimate preformed biofilms growing in the jugular vein catheters of mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

8-week-old C57BL/6 male mice
Dosage:

3 µg/ml
Administration:

Jugular vein-catheterized, 48 hours, 3 µg/ml, once
Result:

Inhibited 67% of fungal biofilm growth and viability, compared to the control untreated biofilms.

Chemical Information

CAS. Nr. 22573-93-9
Molecular Weight 508.79
Formel C₂₆H₅₆N₁₀
SMILES

N=C(NCC(CC)CCCC)NC(NCCCCCCNC(NC(NCC(CC)CCCC)=N)=N)=N
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (5)

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Cell Death Dis

Pharmacological targeting of the mitochondrial phosphatase PTPMT1 sensitizes hepatocellular carcinoma to ferroptosis. [Abstract]

2025 Apr 6;16(1):257. PMID: 40189563
Free Radic Biol Med

Alexidine dihydrochloride enhances the sensitivity of human hepatocellular carcinoma to disulfidptosis via ATF4-DDIT3 activation. [Abstract]

2025 Jun 14:237:585-599. PMID: 40518125
Cell Rep

A generalized strategy to kill leukemic cells by targeting the regulatory systems governing mitochondrial membrane potential. [Abstract]

2025 Nov 25;44(11):116496. PMID: 41166305
Biochem Biophys Res Commun

Mechanisms of NMDA receptor inhibition by chlorhexidine and alexidine. [Abstract]

2026 Jan 18:796:153158. PMID: 41418346
bioRxiv

2024 Nov 06.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zeinab Mamouei, et al. Alexidine Dihydrochloride Has Broad-Spectrum Activities against Diverse Fungal Pathogens. mSphere. 2018 Oct 31;3(5):e00539-18. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Alexidine

5 Cited Publications

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- In Vitro
- In Vivo
Chemical Information
Publications (5)
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Alexidine

Publications Citing Use of MedChemExpress (MCE) Alexidine

Biologische Aktivität

Chemical Information

Publications (5)

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Alexidine Related Classifications

HY-B1474 Related Classifications

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