(4S)-Anthelvencin
(4S)-Anthelvencin is a pyrrolamide metabolite with moderate antibacterial and anthelmintic activities.
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- CAS. Nr.: 58616-25-4
- Formel: C19H25N9O3
- Molecular Weight:427.46
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CCRF-CEM | EC50 |
88 μM
Compound: 4a
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Inhibitory activity against HIV-1 in T4-lymphocytes (CEM cell line).
Inhibitory activity against HIV-1 in T4-lymphocytes (CEM cell line).
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[PMID: 1322989] |
| CCRF-CEM | IC50 |
750 μM
Compound: 4a
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Inhibition of T4-lymphocytes (CEM cell line) infected with HIV-1.
Inhibition of T4-lymphocytes (CEM cell line) infected with HIV-1.
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[PMID: 1322989] |
Chemical Information
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CAS. Nr. 58616-25-4
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Molecular Weight 427.46
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Formel C19H25N9O3
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SMILES
N=C(N)CCNC(C1=CC(NC(C2=CC(NC([C@H]3N=C(CC3)N)=O)=CN2)=O)=CN1C)=O
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Structure Classification
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Initial Source
Streptomyces venezuelae ATCC 14583 and 14585
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
(4S)-Anthelvencin Related Classifications
HY-169507 Related Classifications
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