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Anticancer agent 55

Anticancer agent 55 is a potent anticancer agent. Anticancer agent 55 shows anticancer activity via reducing the cell viability and cell migration in a dose-dependent manner. Anticancer agent 55 induces apoptosis. Anticancer agent 55 has the potential for the research of prostate cancer and breast cancer.

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CAS. Nr.: 2408800-91-7
Formel: C₂₈H₂₁Br₂FN₂O₂
Molecular Weight:596.28

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

Anticancer agent 55 Chemical Structure

CAS. Nr.: 2408800-91-7

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	IC₅₀	1.95 μM Compound: 3h	Cytotoxicity against human MCF7 cells assessed as reduction cell viability incubated for 48 hrs by MTS assay Cytotoxicity against human MCF7 cells assessed as reduction cell viability incubated for 48 hrs by MTS assay	[PMID: 31901746]
PC-3	IC₅₀	1.18 μM Compound: 3h	Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay	[PMID: 31901746]

In Vitro

Anticancer agent 55 (compound 3h) (0-100 μM; 48 h) inhibits cell viability with IC₅₀s of 1.18 μM and 1.95 μM for PC-3, MCF-7 cells, respectively^[1].
Anticancer agent 55 (0, 1, 3, 10 μM; 24 h) inhibits cell migration of PC-3 cells and MCF-7 cells in a dose-dependent manner^[1].
Anticancer agent 55 (0, 1, 3, 10 μM; 12, 24 h) induces apoptosis by increases the caspase-3 activity and cleaved PARP levels^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

PC-3, MCF-7 cells
Concentration:

0-100 µM
Incubation Time:

48 h
Result:

Significantly inhibited cell viability of PC-3, MCF-7 cells with IC₅₀s of 1.18 µM and 1.95 µM, respectively.

Apoptosis Analysis^[1]

Cell Line:

PC-3, MCF-7 cells
Concentration:

0, 1, 3, 10 µM
Incubation Time:

PC-3 for 12 h; MCF-7 for 24 h
Result:

Induced apoptosis by increased the caspase-3 activity in a concentration-dependent manner.

Western Blot Analysis^[1]

Cell Line:

PC-3, MCF-7 cells
Concentration:

0, 1, 3, 10 µM
Incubation Time:

PC-3 for 12 h; MCF-7 for 24 h
Result:

Increased cleaved PARP levels in a dose-dependent manner in PC-3 and MCF-7 cells.

Chemical Information

CAS. Nr. 2408800-91-7
Molecular Weight 596.28
Formel C₂₈H₂₁Br₂FN₂O₂
SMILES

O=C(C1=CC=CC=C1)C[N+]2=CC3=CC=CN3[C@@H](C2C4=CC=C(C=C4)Br)C(C5=CC=C(C=C5)F)=O.[Br-]
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Seo Y, et al. Expansion of chemical space based on a pyrrolo[1,2-a]pyrazine core: Synthesis and its anticancer activity in prostate cancer and breast cancer cells. Eur J Med Chem. 2020 Feb 15;188:111988. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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