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Art. -Nr.: HY-N11738

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Aspalathin

Aspalathin is a C-glycosyldihydrochalcone flavonoid and antioxidant.Aspalathin functions as an antimutagen.Aspalathin can be absorbed by pig intestine as a C-glycoside, and can also be cleaved into its aglycone and sugar moiety.Aspalathin is found in Aspalathus linearis (rooibos).

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CAS. Nr.: 6027-43-6
Formel: C₂₁H₂₄O₁₁
Molecular Weight:452.41

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Aspalathin Chemical Structure

CAS. Nr.: 6027-43-6

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Aspalathin (5 μg/mL) with optimized β-D-glucuronidase treatment (2096 U/mL for urine; 4611.2 U/mL for plasma) and SPE cleanup procedures achieves measurable recovery of aspalathin from spiked blank urine and plasma samples, with plasma showing higher recovery and variable precision depending on enzymatic treatment. Incubation times were 3 h for urine and 1 h for plasma enzymatic treatment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Aspalathin (157-167 mg/kg body weight; p.o.; daily; 11 days) is absorbed in pigs as a C-glycoside and undergoes phase II metabolism to form methylated and glucuronidated conjugates, with 0.1-0.9% of the administered dose excreted in urine, while no aspalathin or metabolites are detectable in plasma^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Female Pig (6 months old, 94-99 kg)^[1]
Dosage:

157 mg/kg ; 167 mg/kg
Administration:

p.o.; daily; 11 days
Result:

Identified six substances derived from aspalathin in urine: parent aspalathin, methylated aspalathin, glucuronidated aspalathin, glucuronidated and methylated aspalathin, a glucuronidated aglycone of aspalathin, and a methylated eriodictyol metabolite with two glucuronic acid moieties.
Detected methylated aspalathin as the major metabolite in enzymatically treated urine samples.

Chemical Information

CAS. Nr. 6027-43-6
Molecular Weight 452.41
Formel C₂₁H₂₄O₁₁
SMILES

O[C@H]1[C@H](C2=C(C(C(CCC3=CC(O)=C(C=C3)O)=O)=C(C=C2O)O)O)O[C@@H]([C@H]([C@@H]1O)O)CO
Structure Classification
- Phenols
- Polyphenols
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Kreuz S, et al. Aspalathin, a flavonoid in Aspalathus linearis (rooibos), is absorbed by pig intestine as a C-glycoside. Nutr Res. 2008;28(10):690-701. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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