Borocaptate sodium
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Borocaptate sodium is a boron-containing compound that can be used as a therapeutic agent in boron neutron capture therapy (BNCT), exhibiting anticancer activity.
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- Reinheit: 95.00%
- CAS. Nr.: 144885-51-8
- Formel: C12H5B2Na2S2+
- Molecular Weight:219.87
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Speicherung:
-20°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Borocaptate sodium (60 μg 10B/mL, 24 hours) combined with BSO (HY-106376) enhances boron uptake and inhibits cell viability in mouse squamous carcinoma cells, rat glioma cells, and hamster lung cells, with boron uptake increasing as cell viability decreases[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Mouse squamous cell carcinoma SCCVII, rat glioma cell line C6, Chinese hamster V79 cells.
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Concentration:60 μg 10B/mL (Each milliliter of Borocaptate sodium solution contains 60 µg of boron-10 isotope (10B))
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Incubation Time:24 h
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Result:Increased boron uptake in tumor cells by 19.2%-34.4% and enhanced the inhibitory effect on cell viability (combined with BSO (HY-106376), a glutathione inhibitor).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Spontaneous intracranial tumor-bearing dogs (primarily gliomas, mixed breed dogs, typically between 5-10 years old, weight 20-30 kg)[2]
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Dosage:55 mg/kg
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Administration:Intravenous injection (i.v.), single dose
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Result:Resulted in boron concentrations of 35.9 µg/g in the tumor at 2 hours, 22.5 µg/g at 6 hours, and 7.0 µg/g at 12 hours. The boron concentration in the tumor was higher than that in normal brain tissue, with a favorable tumor-to-brain ratio.
Chemical Information
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CAS. Nr. 144885-51-8
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Appearance Solid
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Molecular Weight 219.87
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Formel C12H5B2Na2S2+
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Color Off-white to light yellow
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SMILES
SB1234c567c89%10c%11%12%13c581C%11%142c%15%163c%12%17%14c%13%189c6%19%10c%1574c%17%16%18%19.C[BH].[2Na+].[2-]
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Synonyms
BSH
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
Lösungsmittel & Löslichkeit
H2O : 175 mg/mL (795.92 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (279 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Bendel P, et al. Optimal detection of the neutron capture therapy agent borocaptate sodium (BSH): A comparison between and NMR[J]. Medical Physics, 2001, 28(2): 178-183. [Content Brief]
[2]. Kraft SL, et al. Borocaptate sodium: a potential boron delivery compound for boron neutron capture therapy evaluated in dogs with spontaneous intracranial tumors. Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):11973-7. [Content Brief]
[3]. Yoshida F, et al. Enhancement of sodium borocaptate (BSH) uptake by tumor cells induced by glutathione depletion and its radiobiological effect. Cancer Lett. 2004 Nov 8;215(1):61-7. [Content Brief]
[4]. Kokai-Kun J F, et al. Lysostaphin as a treatment for systemic Staphylococcus aureus infection in a mouse model[J]. Journal of antimicrobial chemotherapy, 2007, 60(5): 1051-1059. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.5481 mL | 22.7407 mL | 45.4814 mL | 113.7036 mL |
| 5 mM | 0.9096 mL | 4.5481 mL | 9.0963 mL | 22.7407 mL | |
| 10 mM | 0.4548 mL | 2.2741 mL | 4.5481 mL | 11.3704 mL | |
| 15 mM | 0.3032 mL | 1.5160 mL | 3.0321 mL | 7.5802 mL | |
| 20 mM | 0.2274 mL | 1.1370 mL | 2.2741 mL | 5.6852 mL | |
| 25 mM | 0.1819 mL | 0.9096 mL | 1.8193 mL | 4.5481 mL | |
| 30 mM | 0.1516 mL | 0.7580 mL | 1.5160 mL | 3.7901 mL | |
| 40 mM | 0.1137 mL | 0.5685 mL | 1.1370 mL | 2.8426 mL | |
| 50 mM | 0.0910 mL | 0.4548 mL | 0.9096 mL | 2.2741 mL | |
| 60 mM | 0.0758 mL | 0.3790 mL | 0.7580 mL | 1.8951 mL | |
| 80 mM | 0.0569 mL | 0.2843 mL | 0.5685 mL | 1.4213 mL | |
| 100 mM | 0.0455 mL | 0.2274 mL | 0.4548 mL | 1.1370 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Borocaptate sodium Related Classifications
HY-142041 Related Classifications
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