Brickellin
Brickellin is an antioxidant agent that can be isolated from Varronia curassavica Jacq.. Brickellin inhibits advanced glycation end products (AGEs) formation, protein crosslinking, and oxidative damage to proteins. Brickellin can be used for the research of diabetes.
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- CAS. Nr.: 90357-63-4
- Formel: C20H20O9
- Molecular Weight:404.37
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| KB | ED50 |
>25 μg/mL
Compound: brickellin
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Cytotoxicity against human KB cells after 72 hrs
Cytotoxicity against human KB cells after 72 hrs
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[PMID: 1955888] |
| KB | ED50 |
25 μg/mL
Compound: brickellin
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Cytotoxicity against human KB cells after 72 hrs
Cytotoxicity against human KB cells after 72 hrs
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[PMID: 1955888] |
Brickellin (72 h) does not significantly inhibit the growth of KB cells in vitro, with an ED50 value >25 μg/mL[1].
Brickellin (0.031-0.125 mM; 8 days) significantly inhibits methylglyoxal-induced fluorescent advanced glycation end-product formation in bovine serum albumin in a concentration-dependent manner, with 0.125 mM brickellin reducing AGE formation by 60.8% on day 8[2].
Brickellin (0.031-0.125 mM; 8 days) significantly reduces methylglyoxal-induced formation of dityrosine, N′-formylkynurenine, and kynurenine oxidation markers in bovine serum albumin in a concentration-dependent manner[2].
Brickellin (0.031-0.125 mM; 8 days) inhibits methylglyoxal-induced protein carbonyl formation in bovine serum albumin after 8 days of incubation[2].
Brickellin binds strongly to the SARS-CoV-2 Mpro predicted allosteric site[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 90357-63-4
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Molecular Weight 404.37
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Formel C20H20O9
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SMILES
O=C1C(OC)=C(OC2=CC(OC)=C(OC)C(O)=C12)C=3C=C(OC)C(OC)=CC3O
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Arisawa M, et al. Isolation and cytotoxicity of two new flavonoids from Chrysosplenium grayanum and related flavonols. J Nat Prod. 1991;54(3):898-901. [Content Brief]
[2]. Rodrigues WD, et al. In Vitro Antiglycation Potential of Erva-Baleeira (Varronia curassavica Jacq.). Antioxidants (Basel). 2023 Feb 19;12(2):522. [Content Brief]
[3]. Kubra B, Badshah SL, Faisal S, Sharaf M, Emwas AH, Jaremko M, Abdalla M. Inhibition of the predicted allosteric site of the SARS-CoV-2 main protease through flavonoids. J Biomol Struct Dyn. 2023 Oct-Nov;41(18):9103-9120. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Brickellin Related Classifications
HY-N13261 Related Classifications
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