C10 Bisphosphonate
Based on 1 Customer Validation
C10 Bisphosphonate is an acid sphingomyelinase (aSMase) inhibitor with an IC50 of 0.02 μM in rats. C10 Bisphosphonate inhibits Dexamethasone (HY-14648)-induced cell apoptosis (apoptosis) and alleviates platelet-activating factor (PAF)-induced pulmonary edema. C10 Bisphosphonate can be used for the research of pulmonary edema.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 98.87%
- CAS. Nr.: 15049-93-1
- Formel: C10H25NO6P2
- Molecular Weight:317.26
-
Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Protokoll
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Alle Phospholipase Isoform-spezifische Produkte anzeigen
More
Biologische Aktivität
Beschreibung
In Vitro
C10 Bisphosphonate (compound 7c) potently inhibits aSMase derived from crude rat brain extracts, with an IC50 of 0.02 μM[1].
C10 Bisphosphonate (0.1 μM; 7 h) effectively inhibits Dexamethasone (HY-14648)-induced apoptosis of HepG2 hepatocytes[1].
C10 Bisphosphonate (0.1-1 μM) reduces PAF-induced pulmonary edema in isolated perfused rats in a concentration-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HepG2 liver cells
-
Concentration:0.1 μM
-
Incubation Time:7 h
-
Result:Efficiently inhibited dexamethasone-induced apoptosis, as measured by reduced absorbance in a DNA-fragmentation ELISA.
Chemical Information
-
CAS. Nr. 15049-93-1
-
Appearance Solid
-
Molecular Weight 317.26
-
Formel C10H25NO6P2
-
Color White to off-white
-
SMILES
O=P(O)(C(CCCCCCCCC)(P(O)(O)=O)N)O
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Reinheit & Dokumentation
-
Data Sheet (266 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
C10 Bisphosphonate Related Classifications
HY-48917 Related Classifications
Powered by Bioz