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Art. -Nr.: HY-154831

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C22-Ceramide (d18:1/22:0)

Name: C22-Ceramide (d18:1/22:0)
Brand: MedChemExpress
SKU: HY-154831
Price: 40.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: N-Behenoyl-D-erythro-sphingosine; C22-Ceramide; Cer d18:1/22:0)

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C22-Ceramide (d18:1/22:0) (N-Behenoyl-D-erythro-sphingosine) is an ultra-long-chain ceramide containing a C22:0 behenoyl acyl chain. C22-Ceramide can be glycosylated via CGT-3 to form C22 glucosylceramide (C22 GlcCer), which in turn maintains clathrin membrane localization and lysosomal homeostasis, inhibits TOR signaling and promotes SKN-1 activation, thereby enhancing oxidative stress resistance and extending the lifespan of C. elegans. C22-Ceramide can be used in research on cardiometabolic diseases such as type 2 diabetes, obesity, dyslipidemia, coronary artery disease and thin-cap fibroatheroma (TCFA), as well as oxidative stress and aging-related studies.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit : 99.89%
CAS. Nr.: 27888-44-4
Formel: C₄₀H₇₉NO₃
Molecular Weight:622.06

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

C22-Ceramide (d18:1/22:0) Chemical Structure

CAS. Nr.: 27888-44-4

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Adaptive Immunity

C22-Ceramide (d18:1/22:0) (N-Behenoyl-D-erythro-sphingosine) (10 μM; 3 d) does not significantly inhibit the differentiation of naïve CD4⁺ T cells from C57BL/6 mice into pathogenic Th17 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Oxidative Stress

Dietary supplementation with C22-Ceramide (d18:1/22:0) at 60 μg/NGM plate induces the expression of gst-4p::GFP and SKN-1 target genes, enhances resistance to TBHP-induced oxidative stress, and extends lifespan in intact wild-type C. elegans. skn-1 RNAi completely abolishes the TBHP resistance-enhancing effect of C22-Ceramide, while cgt-3 RNAi also impairs its oxidative stress resistance, indicating that this effect depends on SKN-1 and CGT-3^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS. Nr. 27888-44-4
Appearance Solid
Molecular Weight 622.06
Formel C₄₀H₇₉NO₃
Color White to off-white
SMILES

CCCCCCCCCCCCCCCCCCCCCC(N[C@@H](CO)[C@H](O)/C=C/CCCCCCCCCCCCC)=O
Synonyms

N-Behenoyl-D-erythro-sphingosine; C22-Ceramide; Cer d18:1/22:0
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Lösungsmittel & Löslichkeit

In Vitro:

Ethanol : 5 mg/mL (8.04 mM; ultrasonic and warming and heat to 60°C)

DMF : 0.33 mg/mL (0.53 mM; ultrasonic and warming and heat to 60°C)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.6076 mL

8.0378 mL

16.0756 mL

5 mM

0.3215 mL

1.6076 mL

3.2151 mL

10 mM

---

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Aslan İ, et al. Sphingolipidomic profile and HDL subfractions in obese dyslipidemic type 2 diabetic patients. Prostaglandins & other lipid mediators. 2023 Jun;166:106719.

[2]. Liu H, et al. Endogenous Ceramide 24:1 Constrains Th17-Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2026 May;13(29):e20695. [Content Brief]

[3]. Gong Y, et al. Identification of Plasma Lipidomic Signatures Associated with Coronary Plaque Vulnerability. Journal of cardiovascular translational research. 2025 Oct;18(5):1019-1031.

[4]. Wang F, et al. Saturated very long chain fatty acid configures glycosphingolipid for lysosome homeostasis in long-lived C. elegans. Nat Commun. 2021;12:5073.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
Ethanol	1 mM	1.6076 mL	8.0378 mL	16.0756 mL	40.1890 mL
Ethanol	5 mM	0.3215 mL	1.6076 mL	3.2151 mL	8.0378 mL

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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