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Art. -Nr.: HY-15242

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Capromorelin

(Synonyms: CP 424391)

Capromorelin (CP 424391) is a pyrazolinone-piperidine dipeptide. Capromorelin is an orally active and potent growth hormone secretagogue (GHS) (hGHS-R1a K_i=7 nM, rat pituicyte EC₅₀=3 nM).

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CAS. Nr.: 193273-66-4
Formel: C₂₈H₃₅N₅O₄
Molecular Weight:505.61

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Capromorelin Chemical Structure

CAS. Nr.: 193273-66-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

GHSR1a

7 nM (Ki)

Alle GHSR Isoform-spezifische Produkte anzeigen :

GHSR1a

Cellular Effect

Cell Line	Type	Value	Description	References
Pituitary gland cell	EC₅₀	3 nM Compound: CP 424 391-18	Stimulation of growth hormone secretion in Wistar rat pituitary cells measured after 15 mins Stimulation of growth hormone secretion in Wistar rat pituitary cells measured after 15 mins	[PMID: 35344905]
Pituitary gland cell	EC₅₀	3 nM Compound: 3, (Capromorelin, (CP-424391-18))	In vitro effective concentration required for 50% stimulation of GH release in rat pituitary cell cultures. In vitro effective concentration required for 50% stimulation of GH release in rat pituitary cell cultures.	[PMID: 12392732]
Pituitary gland cell	IC₅₀	3 μM Compound: 3	The effective concentration against rat pituitary cell GH release assay The effective concentration against rat pituitary cell GH release assay	[PMID: 10636230]

In Vivo

Capromorelin increases plasma GH levels in an anesthesized rat model, with an ED₅₀ value less than 0.05 mg/kg iv^[1].
Capromorelin shows enhanced intestinal absorption in rodent models and exhibited superior pharmacokinetic properties, including high bioavailabilities in two animal species [F(rat)=65%, F(dog)=44%]^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 193273-66-4
Molecular Weight 505.61
Formel C₂₈H₃₅N₅O₄
SMILES

CN(C1=O)N=C(CCN(C2)C([C@H](NC(C(C)(N)C)=O)COCC3=CC=CC=C3)=O)[C@]12CC4=CC=CC=C4
Synonyms

CP 424391
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Carpino PA, et al. Pyrazolinone-piperidine dipeptide growth hormone secretagogues (GHSs). Discovery of capromorelin. Bioorg Med Chem. 2003 Feb 20;11(4):581-90. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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Capromorelin

Alle GHSR Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Capromorelin Related Classifications

HY-15242 Related Classifications