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Art. -Nr.: HY-146184

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CCT373567

CCT373567 is a potent molecular glue degrader of transcriptional repressor BCL6, with an IC₅₀ of 2.9 nM. CCT373567 exhibits antiproliferative activity.

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CAS. Nr.: 2378853-67-7
Formel: C₂₆H₂₉ClF₂N₆O₃
Molecular Weight:547.00

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

CCT373567 Chemical Structure

CAS. Nr.: 2378853-67-7

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

CCT373567 is a potent molecular glue degrader of transcriptional repressor BCL6, with an IC₅₀ of 2.9 nM. CCT373567 exhibits antiproliferative activity^[1].

Alle Bcl-2 Family Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HT	GI₅₀	362 nM Compound: 12b; CCT373567	Antiproliferative activity against human HT cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay Antiproliferative activity against human HT cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay	[PMID: 35653645]
KARPAS-422	GI₅₀	38 nM Compound: 12b; CCT373567	Antiproliferative activity against human KARPAS-422 cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay Antiproliferative activity against human KARPAS-422 cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay	[PMID: 35653645]
OCI-Ly1	GI₅₀	83 nM Compound: 12b; CCT373567	Antiproliferative activity against human OCI-Ly1 cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay Antiproliferative activity against human OCI-Ly1 cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay	[PMID: 35653645]
OCI-Ly3	GI₅₀	2145 nM Compound: 12b; CCT373567	Antiproliferative activity against human OCILY3 cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay Antiproliferative activity against human OCILY3 cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay	[PMID: 35653645]
SUD4	GI₅₀	820 nM Compound: 12b; CCT373567	Antiproliferative activity against human SU-DHL-4 cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay Antiproliferative activity against human SU-DHL-4 cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay	[PMID: 35653645]

Chemical Information

CAS. Nr. 2378853-67-7
Molecular Weight 547.00
Formel C₂₆H₂₉ClF₂N₆O₃
SMILES

O=C1N(C)C2=C(C=C(NC3=NC(N4C[C@@H](O)C[C@@H](C)C4)=NC=C3Cl)C=C2)C5=C1OCC(F)(F)[C@H](C6CC6)N5
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Huckvale R, et, al. Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 In Vivo. J Med Chem. 2022 Jun 23;65(12):8191-8207. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
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Chemical Information
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CCT373567

Alle Bcl-2 Family Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

CCT373567 Related Classifications

HY-146184 Related Classifications