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Art. -Nr.: HY-168093

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Cetzole

Cetzole (Compound 1) is a ferroptosis inducer that induces cell death through ROS accumulation. The CC₅₀ values of Cetzole for NCI-H522, NCI-H522 GFP-SCL7A11 #8, NCI-H522 RV-GFP, HT-1080, NARF2, and MDA-MB-231 are 2.56, 10.31, 2.71, 3.07, 14.9, and 6.28 μM, respectively. Cetzole holds potential for research in the field of cancer.

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CAS. Nr.: 3043764-86-6
Formel: C₁₁H₁₁NOS
Molecular Weight:205.28

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (240 KB)

Cetzole Chemical Structure

CAS. Nr.: 3043764-86-6

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Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
HT-1080	CC₅₀	3.07 μM Compound: 1	Cytotoxicity against human HT-1080 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis Cytotoxicity against human HT-1080 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis	[PMID: 39264826]
MDA-MB-231	CC₅₀	6.28 μM Compound: 1	Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis	[PMID: 39264826]
MEF	CC₅₀	2.41 μM Compound: 1	Cytotoxicity against mouse MEF cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis Cytotoxicity against mouse MEF cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis	[PMID: 39264826]
NCI-H522	CC₅₀	10.31 μM Compound: 1	Cytotoxicity against human NCI-H522 cells overexpressing GFP-tagged SLC7A11 assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis Cytotoxicity against human NCI-H522 cells overexpressing GFP-tagged SLC7A11 assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis	[PMID: 39264826]
NCI-H522	CC₅₀	2.56 μM Compound: 1	Cytotoxicity against human NCI-H522 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis Cytotoxicity against human NCI-H522 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis	[PMID: 39264826]
NCI-H522	CC₅₀	2.71 μM Compound: 1	Cytotoxicity against human NCI-H522 cells overexpressing GFP-tagged RV assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis Cytotoxicity against human NCI-H522 cells overexpressing GFP-tagged RV assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis	[PMID: 39264826]
U2OS	CC₅₀	14.9 μM Compound: 1	Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis	[PMID: 39264826]
WI-38	CC₅₀	2.51 μM Compound: 1	Cytotoxicity against human WI-38 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis Cytotoxicity against human WI-38 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis	[PMID: 39264826]

Chemical Information

CAS. Nr. 3043764-86-6
Molecular Weight 205.28
Formel C₁₁H₁₁NOS
SMILES

C#CC1=NC(C2=C(C)C(O)CC2)=CS1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.