Art. -Nr.: HY-N7144A

Citronellyl acetate

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Citronellyl acetate, a monoterpene product of the secondary metabolism of plants, is an orally active antinociceptive agent. Citronellyl acetate modulates TRPV1, TRPM8, ASIC, glutamate receptors, PKC, and PKA-mediated nociception. Citronellyl acetate can be used for the research of acute pain.

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Reinheit: 98.0%
CAS. Nr.: 150-84-5
Formel: C₁₂H₂₂O₂
Molecular Weight:198.30

Speicherung:

Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Citronellyl acetate Chemical Structure

CAS. Nr.: 150-84-5

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

TRPV1

TRPM8

Alle PKA Isoform-spezifische Produkte anzeigen :

Alle TRP Channel Isoform-spezifische Produkte anzeigen :

Alle PKC Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	12.2 μM Compound: 3a	Agonist activity at rat TRPA1 expressed in HEK293 cells assessed as increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry Agonist activity at rat TRPA1 expressed in HEK293 cells assessed as increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry	[PMID: 25455494]
HEK293	IC₅₀	>100 μM Compound: 3a	Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry	[PMID: 25455494]
HEK293	IC₅₀	>100 μM Compound: 3a	Antagonist activity against rat TRPA1 expressed in HEK293 cells assessed as inhibition of AITC-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry Antagonist activity against rat TRPA1 expressed in HEK293 cells assessed as inhibition of AITC-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry	[PMID: 25455494]
HEK293	IC₅₀	>100 μM Compound: 3a	Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry	[PMID: 25455494]

In Vivo

Citronellyl acetate (25-200 mg/kg; i.g.; single dose; 30-360 minutes pre-Acetic acid) produces dose-dependent antinociceptive activity in the Acetic acid (HY-Y0319)-induced writhing model, with an ED₅₀ of 74.42 mg/kg, and the 200 mg/kg dose maintains effects for up to 4 hours post-administration^[1].
Citronellyl acetate (100-200 mg/kg; p.o.; single dose; 30 or 60 minutes pre-formalin) produces significant antinociception in both the neurogenic and inflammatory phases of the formalin-induced paw-licking model^[1].
Citronellyl acetate (100-200 mg/kg; p.o.; single dose; 30 or 60 minutes pre-glutamate) inhibits glutamate-induced nociceptive behavior, indicating involvement of glutamate receptors in its antinociceptive mechanism^[1].
Citronellyl acetate (100-200 mg/kg; p.o.; single dose; 30 or 60 minutes pre-capsaicin) inhibits TRPV1-mediated nociception induced by Capsaicin (HY-10448)^[1].
Citronellyl acetate (100-200 mg/kg; p.o.; single dose; 30 or 60 minutes pre-menthol) inhibits TRPM8-mediated nociception induced by menthol^[1].
Citronellyl acetate (100-200 mg/kg; p.o.; single dose; 30 or 60 minutes pre-acidified saline) inhibits ASIC-mediated nociception induced by acidified saline^[1].
Citronellyl acetate (200 mg/kg; p.o.; single dose; 30 or 60 minutes pre-PMA) inhibits PKC-mediated nociception induced by PMA (HY-18739)^[1].
Citronellyl acetate (200 mg/kg; p.o.; single dose; 30 or 60 minutes pre-8-Br-cAMP) inhibits PKA-mediated nociception induced by 8-Br-cAMP (HY-12306A)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Swiss mice with Acetic acid -induced writhing model (male, 4+ weeks old, 26-32 g)^[1]
Dosage:

25, 50, 75, 100, 200 mg/kg
Administration:

i.g.; single dose; 30-360 minutes pre-acetic acid
Result:

Determined an ED₅₀ of 74.42 mg/kg for antinociceptive activity.
Reduced the number of writhings at 100 and 200 mg/kg.
Exhibited antinociceptive effects from 30 to 240 minutes post-administration at 200 mg/kg, with maximum effect between 60-120 minutes.

Animal Model:

Swiss mice with Formalin-induced paw-licking model (male, 4+ weeks old, 26-32 g)^[1]
Dosage:

100 mg/kg; 200 mg/kg
Administration:

P.o.; single dose; 30 or 60 minutes pre-formalin
Result:

Reduced early phase paw-licking time to 44.63 ± 4.910 seconds at 100 mg/kg.
Reduced late phase paw-licking time to 11.63 ± 2.976 seconds at 100 mg/kg.
Reduced early phase paw-licking time to 44.38 ± 3.836 seconds at 200 mg/kg.
Reduced late phase paw-licking time to 9.875 ± 2.083 seconds at 200 mg/kg.

Chemical Information

CAS. Nr. 150-84-5
Appearance Liquid (Density: 0.891 g/cm³)
Molecular Weight 198.30
Formel C₁₂H₂₂O₂
Color Colorless to light yellow
SMILES

C/C(C)=C\CCC(C)CCOC(C)=O
Structure Classification
- Others
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (504.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

5.0429 mL

25.2143 mL

50.4286 mL

5 mM

1.0086 mL

5.0429 mL

10.0857 mL

10 mM

0.5043 mL

2.5214 mL

5.0429 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (12.61 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (12.61 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (12.61 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
SDS (761 KB)
- English - EN (761 KB)
- Français - FR (761 KB)
- Deutsch - DE (761 KB)
- Norwegian - NO (761 KB)
- Español - ES (761 KB)
- Swedish - SV (761 KB)
- Italian - IT (761 KB)
- Korean - KR (761 KB)
- Portuguese - PT (761 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Rios ER, et al. TRP and ASIC channels mediate the antinociceptive effect of citronellyl acetate. Chem Biol Interact. 2013;203(3):573-579. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	5.0429 mL	25.2143 mL	50.4286 mL	126.0716 mL
	5 mM	1.0086 mL	5.0429 mL	10.0857 mL	25.2143 mL
	10 mM	0.5043 mL	2.5214 mL	5.0429 mL	12.6072 mL
	15 mM	0.3362 mL	1.6810 mL	3.3619 mL	8.4048 mL
	20 mM	0.2521 mL	1.2607 mL	2.5214 mL	6.3036 mL
	25 mM	0.2017 mL	1.0086 mL	2.0171 mL	5.0429 mL
	30 mM	0.1681 mL	0.8405 mL	1.6810 mL	4.2024 mL
	40 mM	0.1261 mL	0.6304 mL	1.2607 mL	3.1518 mL
	50 mM	0.1009 mL	0.5043 mL	1.0086 mL	2.5214 mL
	60 mM	0.0840 mL	0.4202 mL	0.8405 mL	2.1012 mL
	80 mM	0.0630 mL	0.3152 mL	0.6304 mL	1.5759 mL
	100 mM	0.0504 mL	0.2521 mL	0.5043 mL	1.2607 mL

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Citronellyl acetate

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Alle PKA Isoform-spezifische Produkte anzeigen

Alle TRP Channel Isoform-spezifische Produkte anzeigen

Alle PKC Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Citronellyl acetate Related Classifications

HY-N7144A Related Classifications