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Art. -Nr.: HY-N10340

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Clausine E

(Synonyms: Clauszoline I)

Clausine E, is a alkaloid which can be isolated from Clausena excavata, is a inhibitor of fat mass and obesity-associated protein (FTO) demethylase. Clausine E shows inhibitory activities against proliferation of synoviocytes and cancer cells.

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CAS. Nr.: 182261-83-2
Formel: C₁₄H₁₁NO₃
Molecular Weight:241.24

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Clausine E Chemical Structure

CAS. Nr.: 182261-83-2

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Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
CNE-2	IC₅₀	16.9 μM Compound: 3	Growth inhibition human CNE2 cells after 48 hrs by WST-8 based CCK8 assay Growth inhibition human CNE2 cells after 48 hrs by WST-8 based CCK8 assay	[PMID: 22093759]
HCT-116	IC₅₀	1.9 μM Compound: clausine E	Antiproliferative activity against human HCT116 cells after 72 hrs Antiproliferative activity against human HCT116 cells after 72 hrs	[PMID: 17548198]
HeLa	IC₅₀	13.3 μM Compound: 3	Growth inhibition human HeLa cells after 48 hrs by WST-8 based CCK8 assay Growth inhibition human HeLa cells after 48 hrs by WST-8 based CCK8 assay	[PMID: 22093759]
HepG2	IC₅₀	15.8 μM Compound: 3	Growth inhibition of human HepG2 cells after 48 hrs by WST-8 based CCK8 assay Growth inhibition of human HepG2 cells after 48 hrs by WST-8 based CCK8 assay	[PMID: 22093759]
KB	IC₅₀	107.56 μM Compound: 9	Cytotoxicity against human KB cells by resazurin microplate assay Cytotoxicity against human KB cells by resazurin microplate assay	[PMID: 21302964]
L02	IC₅₀	>160 μM Compound: 3	Cytotoxicity human L02 cells after 48 hrs by WST-8 based CCK8 assay Cytotoxicity human L02 cells after 48 hrs by WST-8 based CCK8 assay	[PMID: 22093759]
MCF7	IC₅₀	0.6 μM Compound: clausine E	Antiproliferative activity against human MCF7 cells after 72 hrs Antiproliferative activity against human MCF7 cells after 72 hrs	[PMID: 17548198]
MDA-MB-231	IC₅₀	37.1 μM Compound: 3	Growth inhibition human MDA-MB-231 cells after 48 hrs by WST-8 based CCK8 assay Growth inhibition human MDA-MB-231 cells after 48 hrs by WST-8 based CCK8 assay	[PMID: 22093759]
MES-SA	IC₅₀	35 μM Compound: clausine E	Antiproliferative activity against human Mes-sa cells after 72 hrs Antiproliferative activity against human Mes-sa cells after 72 hrs	[PMID: 17548198]
NCI-H187	IC₅₀	94.59 μM Compound: 9	Cytotoxicity against human NCI-H187 by resazurin microplate assay Cytotoxicity against human NCI-H187 by resazurin microplate assay	[PMID: 21302964]
SW48	IC₅₀	21 μM Compound: clausine E	Antiproliferative activity against human SW48 cells after 72 hrs Antiproliferative activity against human SW48 cells after 72 hrs	[PMID: 17548198]
SW480	IC₅₀	4.8 μM Compound: clausine E	Antiproliferative activity against human SW480 cells after 72 hrs Antiproliferative activity against human SW480 cells after 72 hrs	[PMID: 17548198]
T98G	IC₅₀	71.6 μM Compound: 3	Growth inhibition human T98G cells after 48 hrs by WST-8 based CCK8 assay Growth inhibition human T98G cells after 48 hrs by WST-8 based CCK8 assay	[PMID: 22093759]
Vero	IC₅₀	152.05 μM Compound: 9	Cytotoxicity against african green monkey Vero cells by green fluorescent protein microplate assay Cytotoxicity against african green monkey Vero cells by green fluorescent protein microplate assay	[PMID: 21302964]

Chemical Information

CAS. Nr. 182261-83-2
Molecular Weight 241.24
Formel C₁₄H₁₁NO₃
SMILES

O=C(C1=CC2=C(NC3=C2C=CC=C3)C(O)=C1)OC
Synonyms

Clauszoline I
Structure Classification
- Alkaloids
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Wang Y, Li J, Han X, et al. Identification of Clausine E as an inhibitor of fat mass and obesity-associated protein (FTO) demethylase activity. J Mol Recognit. 2019;32(10):e2800. [Content Brief]

[2]. Guo JM, Yu XM, Jiang B, et al. Zhongguo Zhong Yao Za Zhi. 2021;46(17):4438-4445. [Content Brief]

[3]. Liger F, Popowycz F, Besson T, Picot L, Galmarini CM, Joseph B. Synthesis and antiproliferative activity of clausine E, mukonine, and koenoline bioisosteres. Bioorg Med Chem. 2007;15(16):5615-5619. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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