Art. -Nr.: HY-131060

CN128 hydrochloride

(Synonyms: CN328)

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CN128 hydrochloride (CN328) is an orally active and selective iron chelator. CN128 is used for the research of β-thalassemia.

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Reinheit: 98.15%
CAS. Nr.: 1335282-05-7
Formel: C₁₅H₁₈ClNO₃
Molecular Weight:295.76

Speicherung:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

CN128 hydrochloride Chemical Structure

CAS. Nr.: 1335282-05-7

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

CN128 hydrochloride (CN328) is an orally active and selective iron chelator. CN128 is used for the research of β-thalassemia^[1].

In Vitro

CN128 hydrochloride possesses a high selectivity for iron(III) over others metals^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CN128 hydrochloride (450 μmol/kg; p.o.) exhibits a good iron scavenging efficacy in rat^[1].
The iron removal efficacies of CN128 displays a dose-dependent behavior^[1].
CN128 hydrochloride lacks genetic toxicity^[1].
CN128 hydrochloride (75 μmol/kg; i.g.) possesses good oral bioavailability (82.6%), high maximal plasma concentration, and low clearance rats after an oral dose of 75 μmol/kg^[1].
CN128 hydrochloride is well-tolerated, with no mortality being observed at the higher dose levels in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male SD rats (300 g)^[1]
Dosage:

450 μmol/kg
Administration:

Oral gavage, 1 hour after ⁵⁹Fe-ferritin injection
Result:

Exhibited good iron scavenging activity.

Animal Model:

Sprague-Dawley rats (200~250 g)^[1]
Dosage:

75 μmol/kg (Pharmacokinetic Analysis)
Administration:

Oral administration
Result:

AUC values= 16.38 mg/L•h, C_max=8.671 mg/L.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 1335282-05-7
Appearance Solid
Molecular Weight 295.76
Formel C₁₅H₁₈ClNO₃
Color Off-white to light brown
SMILES

O=C1C(O)=C(C)N([C@@H](CO)CC2=CC=CC=C2)C=C1.[H]Cl
Synonyms

CN328
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Lösungsmittel & Löslichkeit

In Vitro:

H₂O : 100 mg/mL (338.11 mM; Need ultrasonic)

DMSO : 28.57 mg/mL (96.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.3811 mL

16.9056 mL

33.8112 mL

5 mM

0.6762 mL

3.3811 mL

6.7622 mL

10 mM

0.3381 mL

1.6906 mL

3.3811 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.86 mg/mL (9.67 mM); Clear solution

This protocol yields a clear solution of ≥ 2.86 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (28.6 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.86 mg/mL (9.67 mM); Clear solution

This protocol yields a clear solution of ≥ 2.86 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (28.6 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.86 mg/mL (9.67 mM); Clear solution

This protocol yields a clear solution of ≥ 2.86 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (28.6 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact

MedChemExpress (MCE) .

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Wenteng Chen, et al. CN128: A New Orally Active Hydroxypyridinone Iron Chelator. J Med Chem. 2020 Apr 23;63(8):4215-4226. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / H₂O	1 mM	3.3811 mL	16.9056 mL	33.8112 mL	84.5280 mL
	5 mM	0.6762 mL	3.3811 mL	6.7622 mL	16.9056 mL
	10 mM	0.3381 mL	1.6906 mL	3.3811 mL	8.4528 mL
	15 mM	0.2254 mL	1.1270 mL	2.2541 mL	5.6352 mL
	20 mM	0.1691 mL	0.8453 mL	1.6906 mL	4.2264 mL
	25 mM	0.1352 mL	0.6762 mL	1.3524 mL	3.3811 mL
	30 mM	0.1127 mL	0.5635 mL	1.1270 mL	2.8176 mL
	40 mM	0.0845 mL	0.4226 mL	0.8453 mL	2.1132 mL
	50 mM	0.0676 mL	0.3381 mL	0.6762 mL	1.6906 mL
	60 mM	0.0564 mL	0.2818 mL	0.5635 mL	1.4088 mL
	80 mM	0.0423 mL	0.2113 mL	0.4226 mL	1.0566 mL
H₂O	100 mM	0.0338 mL	0.1691 mL	0.3381 mL	0.8453 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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CN128 hydrochloride

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Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

CN128 hydrochloride

Clinical Compound Library

Drug Repurposing Compound Library

Oxygen Sensing Compound Library

Ferroptosis Compound Library

Targeted Diversity Library

Highly Selective Inhibitors Library

Cell Death Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Drug Repurposing Compound Library Plus

Clinical Compound Library Plus

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

CN128 hydrochloride Related Classifications

HY-131060 Related Classifications