DG1
DG1 (Compound 8Nc) is a Thymidylate Synthase (TS) inhibitor that affects cancer angiogenesis and metabolic reprogramming in NSCLC cells. DG1 can effectively inhibit the expression of CD26, ET-1, FGF-1 and EGF. DG1 also effectively inhibits the proliferation of cancer tissue in the A549 xenograft mouse model.
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- Formel: C19H17N5O5S
- Molecular Weight:427.43
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.96 μM
Compound: 8Nc; DG1
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Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
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[PMID: 37437348] |
| BEAS-2B | CC50 |
136.16 μM
Compound: 8Nc; DG1
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Cytotoxicity against human BEAS-2B cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Cytotoxicity against human BEAS-2B cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
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[PMID: 37437348] |
| Calu-1 | IC50 |
6.77 μM
Compound: 8Nc; DG1
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Antiproliferative activity against human Calu-1 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
Antiproliferative activity against human Calu-1 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
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[PMID: 37437348] |
| NCI-H1975 | IC50 |
0.71 μM
Compound: 8Nc; DG1
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Antiproliferative activity against human NCI-H1975 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
Antiproliferative activity against human NCI-H1975 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
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[PMID: 37437348] |
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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Molecular Weight 427.43
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Formel C19H17N5O5S
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SMILES
O=C1NC(NC=C1S(=O)(NC2=CC=CC(C(N/N=C/C3=CC(C)=CC=C3)=O)=C2)=O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
DG1 Related Classifications
HY-149352 Related Classifications
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