DMG-PEG2000-BR2

DMG-PEG2000-BR2 is composed of three covalently linked components: 1. DMG (dimyristoylglycerol): Lipid anchoring group-a diacylglycerol with two C14 chains, providing moderate membrane anchorage; its short-chain, high-fluidity characteristics enable faster dissociation of PEG-lipids from nanoparticle surfaces, facilitating endosomal escape and cellular uptake. 2. PEG 2000 (polyethylene glycol, molecular weight 2000): Hydrophilic polymer spacer arm-forms a steric hindrance crown around nanoparticles, reducing opsonin activity and reticuloendothelial system (RES) clearance, prolonging circulating half-life, and providing steric separation between the lipid surface and the targeting ligand. 3. BR2 peptide: Targeting/functional ligand-BR2 peptide is a tumor cell-specific targeting peptide that binds to receptors on the surface of tumor cells (especially breast cancer cells) for selective targeted delivery with low cytotoxicity to normal cells.

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