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Art. -Nr.: HY-168374

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DSPE-PEG2000-Mannose

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DSPE-PEG 2000-Mannose is a mannose-containing lipid. DSPE-PEG 2000-Mannose is used to prepare mannose-conjugated Liposome (Man-lipo) for siRNA delivery. Mannose-modified liposomes encapsulating IDO siRNA (Man-lipo-siIDO) preferentially knock down IDO expression in the draining lymph nodes and spleens of melanoma-bearing mice. Man-lipo-siIDO delays the onset time of melanoma and reduces tumor volume.

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Reinheit: 90.0%
CAS. Nr.: 1829524-73-3
Molecular Weight:2000 (Average)

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

DSPE-PEG2000-Mannose Chemical Structure

CAS. Nr.: 1829524-73-3

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
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Beschreibung

In Vitro

DSPE-PEG2000-Mannose (3:10:10:4 molar ratio with DOTAP, DPPC, cholesterol; 10 min hydration, 10 min post-extrusion incubation) was used to prepare mannose-conjugated liposomes (Man-lipo) for siRNA delivery, with formulation steps including lipid mixing, hydration with siRNA-protamine mixture, vortexing, sonication, extrusion, and post-extrusion incubation^[1].
DSPE-PEG2000-Mannose-formulated Man-lipo-siIDO (24 h post-transfection) significantly reduced IDO mRNA levels in mouse bone marrow-derived dendritic cells (DCs) compared to Man-lipo-siScramble control^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Treatment with DSPE-PEG2000-Mannose liposomes encapsulating IDO siRNA (100 μg; i.v.; once 2 days pre-tumor inoculation then once weekly thereafter) significantly prolongs tumor-free survival, reduces tumor burden, inhibits T-cell apoptosis, increases CD8⁺ T-cell populations in tumor-draining lymph nodes, reduces T regulatory cell levels, and enhances tumor antigen-specific T-cell proliferation in melanoma-bearing C57BL/6 mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1829524-73-3
Appearance Solid
Molecular Weight 2000 (Average)
Color White to off-white
SMILES

CCCCCCCCCCCCCCCCCC(O[C@@H](COP(OCCNC(OCCOCCNC(NC1=CC=C(O[C@@H]2[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)C=C1)=S)=O)(O)=O)COC(CCCCCCCCCCCCCCCCC)=O)=O.[n]
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Chem Eng J

2025 Dec 13;527:171849.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 16.67 mg/mL (ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

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Reinheit & Dokumentation

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Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
SDS (251 KB)
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- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Chen D, et al. Targeted siRNA silencing of indoleamine 2, 3-dioxygenase in antigen-presenting cells using mannose-conjugated liposomes: a novel strategy for treatment of melanoma. J Immunother. 2014;37(2):123-134. [Content Brief]

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Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

DSPE-PEG2000-Mannose

1 Cited Publications

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Biologische Aktivität
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Publications (1)
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- In Vitro
- In Vivo Dissolution Calculator
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DSPE-PEG2000-Mannose

Publications Citing Use of MedChemExpress (MCE) DSPE-PEG2000-Mannose

Biologische Aktivität

Chemical Information

Publications (1)

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DSPE-PEG2000-Mannose Related Classifications

Art. -Nr.: HY-168374