Elastatinal
Based on 1 Customer Validation
Elastatinal is a potent and competitive inhibitor of elastase, with a Ki of 0.21 μM. Elastatinal more potently inhibits pancreatic elastase versus leucocyte elastase. Elastatinal shows no activity on human leucocyte chymotrypsin-like protease.
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- Reinheit: 99.9%
- CAS. Nr.: 51798-45-9
- Formel: C21H36N8O7
- Molecular Weight:512.56
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Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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HY-15651
Alvelestat
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HY-17443
Sivelestat
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HY-P0017
Aprotinin
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HY-100397R
Elastatinal (Standard)
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HY-75957
DMP 777
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HY-17443A
Sivelestat sodium
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HY-15891A
GW311616 hydrochloride
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HY-17443B
Sivelestat sodium tetrahydrate
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HY-E70203
Recombinant aprotinin
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HY-15891
GW311616
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HY-15651R
Alvelestat (Standard)
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HY-15652
Freselestat
Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
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| Neutrophil | IC50 |
56450 nM
Compound: Elastatinal
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Antiinflammatory activity in human neutrophils assessed as inhibition of FMLP-induced neutrophil elastase release treated 5 mins before FMLP challenge measured after 10 mins
Antiinflammatory activity in human neutrophils assessed as inhibition of FMLP-induced neutrophil elastase release treated 5 mins before FMLP challenge measured after 10 mins
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[PMID: 20417587] |
Elastatinal inhibits the binding of acetyl-alanyl-alanyl-alanine pnitroanilide and acetyl-alanyl-alanyl-alanine methyl ester to elastase, with Kis of 0.24 μM and 0.21 μM, respectively[1].
Elastatinal (5-20 μM) suppresses the enhanced osteoclast differentiation by neutrophils[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 51798-45-9
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Appearance Solid
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Molecular Weight 512.56
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Formel C21H36N8O7
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Color Off-white to light yellow
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SMILES
O=C[C@H](C)NC([C@H](CCC(N)=O)NC([C@H]([C@@]1([H])NC(N)=NCC1)NC(N[C@H](C(O)=O)CC(C)C)=O)=O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMF : 33 mg/mL (64.38 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Umezawa H. Structures and activities of protease inhibitors of microbial origin. Methods Enzymol. 1976;45:678-95. [Content Brief]
[2]. Feinstein G, et, al. The inhibition of human leucocyte elastase and chymotrypsin-like protease by elastatinal and chymostatin. Biochim Biophys Acta. 1976 May 13;429(3):925-32. [Content Brief]
[3]. Sugisaki R, et, al. Possible involvement of elastase in enhanced osteoclast differentiation by neutrophils through degradation of osteoprotegerin. Bone. 2020 Mar;132:115216. [Content Brief]
[4]. Vidhya R, et, al. Anti-inflammatory effects of troxerutin are mediated through elastase inhibition. Immunopharmacol Immunotoxicol. 2020 Oct;42(5):423-435. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMF | 1 mM | 1.9510 mL | 9.7550 mL | 19.5099 mL | 48.7748 mL |
| 5 mM | 0.3902 mL | 1.9510 mL | 3.9020 mL | 9.7550 mL | |
| 10 mM | 0.1951 mL | 0.9755 mL | 1.9510 mL | 4.8775 mL | |
| 15 mM | 0.1301 mL | 0.6503 mL | 1.3007 mL | 3.2517 mL | |
| 20 mM | 0.0975 mL | 0.4877 mL | 0.9755 mL | 2.4387 mL | |
| 25 mM | 0.0780 mL | 0.3902 mL | 0.7804 mL | 1.9510 mL | |
| 30 mM | 0.0650 mL | 0.3252 mL | 0.6503 mL | 1.6258 mL | |
| 40 mM | 0.0488 mL | 0.2439 mL | 0.4877 mL | 1.2194 mL | |
| 50 mM | 0.0390 mL | 0.1951 mL | 0.3902 mL | 0.9755 mL | |
| 60 mM | 0.0325 mL | 0.1626 mL | 0.3252 mL | 0.8129 mL |
Elastatinal Related Classifications
HY-100397 Related Classifications
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