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Art. -Nr.: HY-150794

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FLDP-8

FLDP-8 is a curcuminoid analogues, has potent anti-cancer effects. FLDP-8 can induce cell death with an IC₅₀ value of 4 μM in LN-18 cells.

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CAS. Nr.: 861968-02-7
Formel: C₂₂H₂₃NO₅
Molecular Weight:381.42

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

FLDP-8 Chemical Structure

CAS. Nr.: 861968-02-7

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

FLDP-8 is a curcuminoid analogues, has potent anti-cancer effects. FLDP-8 can induce cell death with an IC₅₀ value of 4 μM in LN-18 cells^[1].

IC₅₀ & Target

IC50: 4 μM (LN-18 cells)^[1]

In Vitro

FLDP-8 (0-40 μM, 24 h) induces cell death process with an IC₅₀ value of 4 μM in a concentration-dependent manner in LN-18 cells, which involves oxidative stress^[1].
FLDP-8 (1.25 μM, 2.5 μM, 24 h) induces significant S-phase cell cycle arrest^[1].
FLDP-8 (2.5 μM, 5 μM, 24 h) exhibits anti-cancer effects with anti-proliferative, anti-migratory and high potency of BBB permeable properties in Glioblastoma multiforme (GBM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

LN-18 cells and HBEC‑5i cells
Concentration:

0.625 μM -20 μM (LN‑18 cells) 1.25 μM - 40 μM (HBEC‑5i cells)
Incubation Time:

24 h
Result:

Induced cytotoxicity on LN‑18 cells and HBEC‑5i cells.

Cell Cycle Analysis^[1]

Cell Line:

LN-18 cells
Concentration:

1.25 μM, 2.5 μM
Incubation Time:

24 h
Result:

Induced arrest in S phase in a concentration-dependent manner.

Cell Invasion Assay^[1]

Cell Line:

LN-18 cells
Concentration:

2.5 μM, 5 μM
Incubation Time:

24 h
Result:

Inhibited the invasion of LN‑18 cells.

Cell Migration Assay ^[1]

Cell Line:

LN-18 cells
Concentration:

2.5 μM, 5 μM
Incubation Time:

24 h
Result:

Showed a high potential in inhibiting the migration of LN-18 cells.

Chemical Information

CAS. Nr. 861968-02-7
Molecular Weight 381.42
Formel C₂₂H₂₃NO₅
SMILES

O=C1/C(CN(C)C/C1=C\C2=CC=C(O)C(OC)=C2)=C/C3=CC=C(O)C(OC)=C3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Nur Syahirah Che Razali, et al. Curcumin piperidone derivatives induce anti-proliferative and anti-migratory effects in LN-18 human glioblastoma cells. Sci Rep. 2022 Jul 30;12(1):13131. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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