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Art. -Nr.: HY-148969

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FPPS-IN-1

FPPS-IN-1 is a potent non-bisphosphonate Farnesyl pyrophosphate synthase (FPPS) inhibitor with an IC₅₀ 0.2 μM. FPPS-IN-1 can be used for the research of cancers.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 1250273-31-4
Formel: C₁₅H₁₁NO₄
Molecular Weight:269.26

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

FPPS-IN-1 Chemical Structure

CAS. Nr.: 1250273-31-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

FPPS-IN-1 is a potent non-bisphosphonate Farnesyl pyrophosphate synthase (FPPS) inhibitor with an IC₅₀ 0.2 μM. FPPS-IN-1 can be used for the research of cancers^[1].

In Vitro

FPPS-IN-1 (compound 11) has low trans-cellular permeability, medium-to-low Caco-2 permeability, and no measurable bone affinity^[1].
FPPS-IN-1 (30 μM) shows no hERG channel inhibition^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1250273-31-4
Molecular Weight 269.26
Formel C₁₅H₁₁NO₄
SMILES

O=C(O)C1=CC=2C=CC=3C=CC=CC3C2N1CC(=O)O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Jahnke W, et al. Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery. Nat Chem Biol. 2010;6(9):660-666. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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