Gap19
Based on 5 publication(s) in Google Scholar
Gap19, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 has protective effects against myocardial.
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- Reinheit: 99.32%
- CAS. Nr.: 1507930-57-5
- Formel: C55H96N14O13
- Molecular Weight:1161.44
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Speicherung:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Gap19
More
Biologische Aktivität
Cx43 Hemichannel[1]
Gap19 (250 μM; for 30 min ) decreases mitochondrial potassium uptake[1].
Gap19 (400 μM) inhibits unitary hemichannel currents in HeLa-Cx43 cells[2].
Gap19 (100 μM) inhibits hemichannel unitary currents in ventricular cardiomyocytes[2].
Gap19 (250 μM, 30 min) protects against myocardial ischemia/reperfusion injury in vitro and in vivo[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57/BL6 mice[2]
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Dosage:25 mg/kg
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Administration:IV; 10 min before ligation
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Result:Significantly reduced the infarct size by approximately one-fifth.
Chemical Information
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CAS. Nr. 1507930-57-5
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Appearance Solid
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Molecular Weight 1161.44
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Formel C55H96N14O13
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Color White to off-white
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Sequence Shortening
KQIEIKKFK
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (5)
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Journal Impact Factor
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Most Recent
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Br J Pharmacol
A potential therapeutic target at Connexin 43 serine phosphorylation against ischaemia/reperfusion arrhythmia. [Abstract]2025 Jun 9. PMID: 40490933 -
Cell Stress Chaperones
Involvement of oxidative stress-AMPK-Cx43-NLRP3 pathway in extracellular matrix remodeling of gastric smooth muscle cells in rats with diabetic gastroparesis. [Abstract]2024 Jun;29(3):440-455. PMID: 38653383 -
Oral Dis
Connexin43 reduces LPS-induced inflammation in hDPCs through TLR4-NF-κB pathway via hemichannels. [Abstract]2024 Jul;30(5):3239-3249. PMID: 37811593 -
Brain Res
Enriched environment alleviates neurological deficits via downregulation of Cx43 after experimental stroke. [Abstract]2023 Dec 15:1821:148619. PMID: 37805009 -
Lösungsmittel & Löslichkeit
H2O : ≥ 100 mg/mL (86.10 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (279 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Boengler K, et al. Connexin 43 impacts on mitochondrial potassium uptake. Front Pharmacol. 2013 Jun 6;4:73. [Content Brief]
[2]. Wang N, et al. Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury. Basic Res Cardiol. 2013 Jan;108(1):309. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.8610 mL | 4.3050 mL | 8.6100 mL | 21.5250 mL |
| 5 mM | 0.1722 mL | 0.8610 mL | 1.7220 mL | 4.3050 mL | |
| 10 mM | 0.0861 mL | 0.4305 mL | 0.8610 mL | 2.1525 mL | |
| 15 mM | 0.0574 mL | 0.2870 mL | 0.5740 mL | 1.4350 mL | |
| 20 mM | 0.0431 mL | 0.2153 mL | 0.4305 mL | 1.0763 mL | |
| 25 mM | 0.0344 mL | 0.1722 mL | 0.3444 mL | 0.8610 mL | |
| 30 mM | 0.0287 mL | 0.1435 mL | 0.2870 mL | 0.7175 mL | |
| 40 mM | 0.0215 mL | 0.1076 mL | 0.2153 mL | 0.5381 mL | |
| 50 mM | 0.0172 mL | 0.0861 mL | 0.1722 mL | 0.4305 mL | |
| 60 mM | 0.0144 mL | 0.0718 mL | 0.1435 mL | 0.3588 mL | |
| 80 mM | 0.0108 mL | 0.0538 mL | 0.1076 mL | 0.2691 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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