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MTNR1A - melatonin receptor 1A Gene

Also Known as MT1; MEL-1A-R

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4543

About MTNR1A

Cytogenetic location: 4q35.2 Genomic coordinates (GRCh38): 4:186,533,655-186,555,567 (from NCBI)

This gene has 2 transcripts (splice variants), 185 orthologues and 33 paralogues. Biased expression in kidney (RPKM 1.1), testis (RPKM 0.6) and 8 other tissues.

Summary

This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq, Jul 2008]

MTNR1A Products (2)

mRNA	Protein	Name
NM_005958.4	NP_005949.1	melatonin receptor type 1A
XM_011532002.4	XP_011530304.1	melatonin receptor type 1A isoform X1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables hormone binding	IPI IPI: Inferred from physical interaction	10531408	GOA
enables melatonin receptor activity	IDA IDA: Inferred from direct assay	10531408	GOA
enables organic cyclic compound binding	IPI IPI: Inferred from physical interaction	10531408	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17215244	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	10531408	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	10531408	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	10531408	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MTNR1A Protein Structure

7tm_1

0
100
200
300
350 a.a.

Protein Preferred Names	Protein Names
melatonin receptor type 1A	mel1a receptor

MTNR1A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	MTNR1A	P48039	TMEM33	Homo sapiens	P57088	TAP	17215244
Intra	MTNR1A	P48039	TMEM33	Homo sapiens	P57088	TAP	26514267
Intra	MTNR1A	P48039	CALR	Homo sapiens	P27797	Ub Reconstruction	28298427
Intra	MTNR1A	P48039	CALR	Homo sapiens	P27797	TAP	17215244
Intra	MTNR1A	P48039	CALR	Homo sapiens	P27797	TAP	26514267
Intra	MTNR1A	P48039	RGS20	Homo sapiens	O76081	Pull Down	20859254
Intra	MTNR1A	P48039	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Array	32296183
Intra	MTNR1A	P48039	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Prey Pooling	32296183
Intra	MTNR1A	P48039	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	MTNR1A	P48039	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

MTNR1A Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P81119	MTNR1A Antibody	WB, ELISA, IHC-P, IHC-F, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Delayed Sleep Phase Disorder	Delayed Sleep Phase Syndrome Delayed Sleep Phase Syndrome, Susceptibility To DSPD Delayed Sleep Phase Disorder, Susceptibility To DSPS Sleep Phase, Delayed, Disorder Sleep Phase Syndrome, Delayed, Susceptibility To
Major Depressive Disorder	Seasonal Affective Disorder Unipolar Depression Depression MDD Depressive Disorder Unipolar Depression, Susceptibility To Major Depressive Disorder 1 Major Depressive Disorder, Response To Citalopram Therapy In Major Depressive Disorder 2 Winter Depression Single Major Depressive Episode Sad Clinical Depression Major Depression Depressive Syndrome Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment Seasonal Affective Disorder, Susceptibility To Recurrent Major Depression Affective Disorder, Seasonal Depression In A Seasonal Pattern Depression Seasonal Major Depressive Disorder With A Seasonal Pattern Seasonal Depression Seasonal Mood Disorder Mental Depression Recurrent Major Depressive Episodes
Deafness, Autosomal Dominant 24	DFNA24 Autosomal Dominant Nonsyndromic Deafness 24 Autosomal Dominant Deafness 24
Nephrolithiasis	Kidney Stones Stone - Kidney/Ureter Kidney Calculi
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Scoliosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-145700	UCSF648		/	Unkown
HY-RS08803	MTNR1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08804	Mtnr1a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08805	Mtnr1a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MTNR1A	VGNC	VGNC:31746
Canis familiaris	MTNR1A	VGNC	VGNC:110519
Mus musculus	MTNR1A	MGD	MGI:102967
Rattus norvegicus	MTNR1A	RGD	RGD:620797
Macaca mulatta	MTNR1A	VGNC	VGNC:81477
Felis catus	MTNR1A	VGNC	VGNC:78528
Others	MTNR1A	NCBI