PRKCI - protein kinase C iota Gene

Also Known as PKCI; DXS1179E; nPKC-iota

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5584

About PRKCI

Cytogenetic location: 3q26.2 Genomic coordinates (GRCh38): 3:170,222,424-170,305,977 (from NCBI)

This gene has 7 transcripts (splice variants), 226 orthologues and 9 paralogues. Ubiquitous expression in stomach (RPKM 19.1), thyroid (RPKM 17.9) and 24 other tissues.

Summary

This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced Apoptosis and therefore protects leukemia cells against drug-induced Apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008]

PRKCI Products (3)

mRNA	Protein	Name
NM_002740.6	NP_002731.4	protein kinase C iota type
XM_047448574.1	XP_047304530.1	protein kinase C iota type isoform X1
XM_047448575.1	XP_047304531.1	protein kinase C iota type isoform X2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables diacylglycerol-dependent serine/threonine kinase activity	EXP EXP: Inferred from Experiment	12700136	GOA
enables phospholipid binding	IDA IDA: Inferred from direct assay	8226978	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11257119	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	11724794	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	8226978	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in cell-cell junction organization	IMP IMP: Inferred from mutant phenotype	11257119	GOA
involved in establishment or maintenance of epithelial cell apical/basal polarity	IDA IDA: Inferred from direct assay	11257119	GOA
involved in negative regulation of glial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	21419810	GOA
involved in negative regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	10467349	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	10467349	GOA
involved in positive regulation of endothelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	19327373	GOA
involved in positive regulation of glial cell proliferation	IMP IMP: Inferred from mutant phenotype	21419810	GOA
involved in positive regulation of neuron projection development	IDA IDA: Inferred from direct assay	36250347	GOA
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	10467349	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	8226978	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of PAR polarity complex	IPI IPI: Inferred from physical interaction	11257119	GOA
located in cytosol	IDA IDA: Inferred from direct assay	11257119	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11260256	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRKCI Protein Structure

PB1

C1_1

Pkinase

Pkinase_C

0
100
200
300
400
500
596 a.a.

Protein Preferred Names	Protein Names
protein kinase C iota type	PRKC-lambda/iota aPKC-lambda/iota atypical protein kinase C-lambda/iota

PRKCI Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	PRKCI	P41743	ELF3	Homo sapiens	P78545	Anti Bait CoIP	26977885
Intra	PRKCI	P41743	PARD6A	Homo sapiens	Q9NPB6-2	Validated Y2H	32296183
Intra	PRKCI	P41743	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	PRKCI	P41743	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	PRKCI	P41743	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	PRKCI	P41743	PRKCZ	Homo sapiens	Q05513	Anti Tag CoIP	31980649
Intra	PRKCI	P41743	PARD6B	Homo sapiens	Q9BYG5	Validated Y2H	25416956
Intra	PRKCI	P41743	PARD6B	Homo sapiens	Q9BYG5	Pull Down	11260256
Intra	PRKCI	P41743	PARD6B	Homo sapiens	Q9BYG5	Anti Tag CoIP	26496610
Intra	PRKCI	P41743	PARD6B	Homo sapiens	Q9BYG5	Validated Y2H	32296183
Intra	PRKCI	P41743	PARD6B	Homo sapiens	Q9BYG5	Anti Tag CoIP	35271311
Intra	PRKCI	P41743	PARD6B	Homo sapiens	Q9BYG5	Anti Tag CoIP	31980649
Intra	PRKCI	P41743	PARD6B	Homo sapiens	Q9BYG5	Anti Tag CoIP	14676191
Intra	PRKCI	P41743	PARD6B	Homo sapiens	Q9BYG5	Y2H	11260256
Intra	PRKCI	P41743	PARD6G	Homo sapiens	Q9BYG4	Anti Tag CoIP	31980649
Intra	PRKCI	P41743	PARD6G	Homo sapiens	Q9BYG4	Y2H	11260256
Intra	PRKCI	P41743	PARD6G	Homo sapiens	Q9BYG4	Anti Tag CoIP	14676191
Intra	PRKCI	P41743	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	14676191
Intra	PRKCI	P41743	SQSTM1	Homo sapiens	Q13501	Anti Tag CoIP	31980649
Intra	PRKCI	P41743	SQSTM1	Homo sapiens	Q13501	Validated Y2H	32296183
Intra	PRKCI	P41743	SQSTM1	Homo sapiens	Q13501	Y2H Array	32296183
Intra	PRKCI	P41743	SQSTM1	Homo sapiens	Q13501	Anti Bait CoIP	20808283
Intra	PRKCI	P41743	SQSTM1	Homo sapiens	Q13501	Y2H Prey Pooling	32296183
Intra	PRKCI	P41743	SQSTM1	Homo sapiens	Q13501	Anti Tag CoIP	14676191
Intra	PRKCI	P41743	RAC1	Homo sapiens	P63000	Pull Down	11260256
Intra	PRKCI	P41743	SOX2	Homo sapiens	P48431	Protein Kinase Assay	24525231
Intra	PRKCI	P41743	NACC1	Homo sapiens	Q96RE7	Y2H Prey Pooling	32296183
Intra	PRKCI	P41743	NACC1	Homo sapiens	Q96RE7	Validated Y2H	32296183
Intra	PRKCI	P41743	NACC1	Homo sapiens	Q96RE7	Y2H Array	32296183
Intra	PRKCI	P41743	CDC42	Homo sapiens	P60953	Anti Tag CoIP	14676191
Intra	PRKCI	P41743	CDC42	Homo sapiens	P60953	Pull Down	11260256
Intra	PRKCI	P41743	PARD6A	Homo sapiens	Q9NPB6	Anti Tag CoIP	14676191
Intra	PRKCI	P41743	PARD6A	Homo sapiens	Q9NPB6	Y2H Array	25416956
Intra	PRKCI	P41743	PARD6A	Homo sapiens	Q9NPB6	Y2H Pooling	16189514
Intra	PRKCI	P41743	PARD6A	Homo sapiens	Q9NPB6	Y2H	11260256
Intra	PRKCI	P41743	PARD6A	Homo sapiens	Q9NPB6	Y2H Prey Pooling	25416956
Intra	PRKCI	P41743	PARD3	Homo sapiens	Q8TEW0	Anti Tag CoIP	31980649
Intra	PRKCI	P41743	PARD3	Homo sapiens	Q8TEW0	Anti Tag CoIP	14676191

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS11134	PRKCI Human Pre-designed siRNA Set A		/	Unkown
HY-RS11135	Prkci Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS11136	Prkci Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28112	Hint1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PRKCI	VGNC	VGNC:69062
Mus musculus	PRKCI	MGD	MGI:99260
Bos taurus	PRKCI	VGNC	VGNC:33333
Canis familiaris	PRKCI	VGNC	VGNC:44982
Rattus norvegicus	PRKCI	RGD	RGD:620961
Macaca mulatta	PRKCI	VGNC	VGNC:84064
Others	PRKCI	NCBI