BTG1 - BTG anti-proliferation factor 1 Gene

Also Known as APRO2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 694

About BTG1

Cytogenetic location: 12q21.33 Genomic coordinates (GRCh38): 12:92,140,278-92,145,846 (from NCBI)

This gene has 3 transcripts (splice variants), 224 orthologues, 3 paralogues and is associated with 44 phenotypes. Ubiquitous expression in bone marrow (RPKM 117.9), lymph node (RPKM 72.6) and 25 other tissues.

Summary

This gene is a member of an anti-proliferative gene family that regulates cell growth and differentiation. Expression of this gene is highest in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. The encoded protein interacts with several nuclear receptors, and functions as a coactivator of cell differentiation. This locus has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia. [provided by RefSeq, Oct 2008]

BTG1 Products (1)

mRNA	Protein	Name
NM_001731.3	NP_001722.1	protein BTG1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	8663146	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9712883	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
acts upstream of or within negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	11420681	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	1373383	GOA
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	15033446	GOA
involved in positive regulation of endothelial cell differentiation	IMP IMP: Inferred from mutant phenotype	15033446	GOA
involved in positive regulation of fibroblast apoptotic process	IMP IMP: Inferred from mutant phenotype	9690562	GOA
acts upstream of or within positive regulation of myoblast differentiation	IDA IDA: Inferred from direct assay	11420681	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11420681	GOA
located in cytoplasm	IMP IMP: Inferred from mutant phenotype	11420681	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9820826	GOA
located in nucleus	IMP IMP: Inferred from mutant phenotype	11420681	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BTG1 Protein Structure

BTG

0
100
171 a.a.

Protein Preferred Names	Protein Names
protein BTG1	B-cell translocation gene 1 protein

BTG1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Cross	BTG1	P62324	Cnot7	Mus musculus	Q60809	Y2H	9712883
Cross	BTG1	P62324	Cnot7	Mus musculus	Q60809	Pull Down	9712883
Intra	BTG1	P62324	CNOT7	Homo sapiens	Q9UIV1	Y2H	21900206
Intra	BTG1	P62324	CNOT7	Homo sapiens	Q9UIV1	Pull Down	11136725
Intra	BTG1	P62324	CNOT7	Homo sapiens	Q9UIV1	SLC	27107012
Intra	BTG1	P62324	GRB2	Homo sapiens	P62993	Validated Y2H	32296183
Intra	BTG1	P62324	FADD	Homo sapiens	Q13158	Validated Y2H	32296183
Intra	BTG1	P62324	CNOT8	Homo sapiens	Q9UFF9	Y2H Pooling	16189514
Intra	BTG1	P62324	CNOT8	Homo sapiens	Q9UFF9	Y2H	21900206
Intra	BTG1	P62324	CNOT8	Homo sapiens	Q9UFF9	Y2H	11136725
Intra	BTG1	P62324	CNOT8	Homo sapiens	Q9UFF9	Y2H Array	20211142

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Leukemia	Leukemias Leukaemia, Unspecified, Without Mention Of Remission Aleukemic Leukaemia Chronic Leukaemia Subacute Leukaemia Leukaemia Disorder Leukaemia Nos
Intellectual Developmental Disorder, Autosomal Dominant 33	MRD33 Autosomal Dominant Non-Syndromic Intellectual Disability 33 Mental Retardation, Autosomal Dominant 33 Autosomal Dominant Intellectual Developmental Disorder 33 Autosomal Dominant Mental Retardation 33 Mental Retardation, Autosomal Dominant, Type 33
Charcot-Marie-Tooth Disease	Cmt Hmsn Hereditary Motor And Sensory Neuropathy Pma Cmt - Charcot-Marie-Tooth Disease Charcot Marie Tooth Disease Charcot-Marie-Tooth Hereditary Neuropathy Charcot-Marie-Tooth Syndrome Peroneal Muscular Atrophy Hereditary Motor And Sensory Neuropathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS01662	BTG1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10933	PPBP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17038	Ppbp Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20697	Btg1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27208	Btg1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	BTG1	RGD	RGD:2224
Canis familiaris	BTG1	VGNC	VGNC:38558
Bos taurus	BTG1	VGNC	VGNC:26597
Mus musculus	BTG1	MGD	MGI:88215
Others	BTG1	NCBI