ATG13 - autophagy related 13 Gene

Also Known as KIAA0652; PARATARG8

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9776

About ATG13

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:46,617,553-46,674,518 (from NCBI)

This gene has 31 transcripts (splice variants) and 217 orthologues. Ubiquitous expression in testis (RPKM 17.3), brain (RPKM 12.2) and 25 other tissues.

Summary

The protein encoded by this gene is an Autophagy factor and a target of the TOR kinase signaling pathway. The encoded protein is essential for autophagosome formation and Mitophagy. [provided by RefSeq, Oct 2016]

ATG13 Products (51)

mRNA	Protein	Name
NM_001142673.3	NP_001136145.1	autophagy-related protein 13 isoform c
NM_001205119.2	NP_001192048.1	autophagy-related protein 13 isoform a
NM_001205120.2	NP_001192049.1	autophagy-related protein 13 isoform c
NM_001205121.2	NP_001192050.1	autophagy-related protein 13 isoform f
NM_001205122.2	NP_001192051.1	autophagy-related protein 13 isoform h
NM_001346311.2	NP_001333240.1	autophagy-related protein 13 isoform a
NM_001346312.2	NP_001333241.1	autophagy-related protein 13 isoform a
NM_001346313.2	NP_001333242.1	autophagy-related protein 13 isoform a
NM_001346314.2	NP_001333243.1	autophagy-related protein 13 isoform a
NM_001346315.2	NP_001333244.1	autophagy-related protein 13 isoform a
NM_001346316.2	NP_001333245.1	autophagy-related protein 13 isoform a
NM_001346317.2	NP_001333246.1	autophagy-related protein 13 isoform b
NM_001346318.2	NP_001333247.1	autophagy-related protein 13 isoform b
NM_001346319.2	NP_001333248.1	autophagy-related protein 13 isoform c
NM_001346320.2	NP_001333249.1	autophagy-related protein 13 isoform c
NM_001346321.2	NP_001333250.1	autophagy-related protein 13 isoform c
NM_001346322.2	NP_001333251.1	autophagy-related protein 13 isoform c
NM_001346323.2	NP_001333252.1	autophagy-related protein 13 isoform c
NM_001346324.2	NP_001333253.1	autophagy-related protein 13 isoform c
NM_001346325.2	NP_001333254.1	autophagy-related protein 13 isoform c
NM_001346326.2	NP_001333255.1	autophagy-related protein 13 isoform c
NM_001346327.2	NP_001333256.1	autophagy-related protein 13 isoform c
NM_001346328.2	NP_001333257.1	autophagy-related protein 13 isoform c
NM_001346329.2	NP_001333258.1	autophagy-related protein 13 isoform c
NM_001346330.2	NP_001333259.1	autophagy-related protein 13 isoform c
NM_001346331.2	NP_001333260.1	autophagy-related protein 13 isoform c
NM_001346332.2	NP_001333261.1	autophagy-related protein 13 isoform c
NM_001346333.2	NP_001333262.1	autophagy-related protein 13 isoform d
NM_001346334.2	NP_001333263.1	autophagy-related protein 13 isoform d
NM_001346335.2	NP_001333264.1	autophagy-related protein 13 isoform d
NM_001346336.2	NP_001333265.1	autophagy-related protein 13 isoform d
NM_001346337.2	NP_001333266.1	autophagy-related protein 13 isoform d
NM_001346338.2	NP_001333267.1	autophagy-related protein 13 isoform e
NM_001346340.2	NP_001333269.1	autophagy-related protein 13 isoform e
NM_001346342.2	NP_001333271.1	autophagy-related protein 13 isoform f
NM_001346344.2	NP_001333273.1	autophagy-related protein 13 isoform f
NM_001346346.2	NP_001333275.1	autophagy-related protein 13 isoform f
NM_001346348.2	NP_001333277.1	autophagy-related protein 13 isoform f
NM_001346349.2	NP_001333278.1	autophagy-related protein 13 isoform f
NM_001346350.2	NP_001333279.1	autophagy-related protein 13 isoform f
NM_001346351.2	NP_001333280.1	autophagy-related protein 13 isoform f
NM_001346352.2	NP_001333281.1	autophagy-related protein 13 isoform f
NM_001346353.2	NP_001333282.1	autophagy-related protein 13 isoform f
NM_001346354.2	NP_001333283.1	autophagy-related protein 13 isoform f
NM_001346355.2	NP_001333284.1	autophagy-related protein 13 isoform g
NM_001346356.2	NP_001333285.1	autophagy-related protein 13 isoform g
NM_001346357.2	NP_001333286.1	autophagy-related protein 13 isoform i
NM_001346358.2	NP_001333287.1	autophagy-related protein 13 isoform i
NM_001346359.2	NP_001333288.1	autophagy-related protein 13 isoform i
NM_001346360.2	NP_001333289.1	autophagy-related protein 13 isoform j
NM_014741.5	NP_055556.2	autophagy-related protein 13 isoform f

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19211835	GOA
enables protein kinase binding	IDA IDA: Inferred from direct assay	29487085	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	18936157	GOA
enables protein serine/threonine kinase activator activity	IDA IDA: Inferred from direct assay	19225151	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in autophagosome assembly	IDA IDA: Inferred from direct assay	19225151	GOA
acts upstream of or within autophagosome assembly	IMP IMP: Inferred from mutant phenotype	19211835	GOA
involved in autophagosome assembly	IMP IMP: Inferred from mutant phenotype	19211835	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	21795849	GOA
involved in positive regulation of autophagy	IDA IDA: Inferred from direct assay	29487085	GOA
involved in regulation of protein lipidation	IDA IDA: Inferred from direct assay	19225151	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of Atg1/ULK1 kinase complex	IPI IPI: Inferred from physical interaction	19211835	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	21855797	GOA
located in phagophore assembly site	IDA IDA: Inferred from direct assay	19597335	GOA
is active in phagophore assembly site membrane	IDA IDA: Inferred from direct assay	19597335	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATG13 Protein Structure

ATG13

0
100
200
300
400
517 a.a.

Protein Preferred Names	Protein Names
autophagy-related protein 13	ATG13 autophagy related 13 homolog

ATG13 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	ATG13	O75143	RB1CC1	Homo sapiens	Q8TDY2	Anti Tag CoIP	20562859
Intra	ATG13	O75143	RB1CC1	Homo sapiens	Q8TDY2	Anti Bait CoIP	33368531
Intra	ATG13	O75143	RB1CC1	Homo sapiens	Q8TDY2	Anti Bait CoIP	19597335
Intra	ATG13	O75143	RB1CC1	Homo sapiens	Q8TDY2	Anti Tag CoIP	35271311
Intra	ATG13	O75143	RB1CC1	Homo sapiens	Q8TDY2	Crosslink	23392225
Intra	ATG13	O75143	MAP1LC3A	Homo sapiens	Q9H492-1	SPR	24290141
Intra	ATG13	O75143	MAP1LC3A	Homo sapiens	Q9H492-1	Y2H	24290141
Intra	ATG13	O75143	MAP1LC3A	Homo sapiens	Q9H492-1	Pull Down	24290141
Intra	ATG13	O75143	C9orf72	Homo sapiens	Q96LT7-1	Pull Down	27334615
Intra	ATG13	O75143	C9orf72	Homo sapiens	Q96LT7-2	Pull Down	27334615
Intra	ATG13	O75143	C9orf72	Homo sapiens	Q96LT7-2	PLA	27334615
Intra	ATG13	O75143	MAP1LC3C	Homo sapiens	Q9BXW4	Pull Down	20562859
Intra	ATG13	O75143	MAP1LC3C	Homo sapiens	Q9BXW4	Pull Down	24290141
Intra	ATG13	O75143	MAP1LC3C	Homo sapiens	Q9BXW4	SPR	24290141
Intra	ATG13	O75143	MAP1LC3C	Homo sapiens	Q9BXW4	Y2H	24290141
Intra	ATG13	O75143	ATG101	Homo sapiens	Q9BSB4	Anti Tag CoIP	20562859
Intra	ATG13	O75143	ATG101	Homo sapiens	Q9BSB4	Ion Exchange Chrom	26299944
Intra	ATG13	O75143	ATG101	Homo sapiens	Q9BSB4	Anti Bait CoIP	19597335
Intra	ATG13	O75143	ATG101	Homo sapiens	Q9BSB4	X-Ray Diffraction	26299944
Intra	ATG13	O75143	ATG101	Homo sapiens	Q9BSB4	Pull Down	26299944
Intra	ATG13	O75143	ATG101	Homo sapiens	Q9BSB4	Y2H	24290141
Intra	ATG13	O75143	ATG101	Homo sapiens	Q9BSB4	GMS	26299944
Intra	ATG13	O75143	ATG101	Homo sapiens	Q9BSB4	Anti Tag CoIP	19597335
Intra	ATG13	O75143	ATG101	Homo sapiens	Q9BSB4	Anti Tag CoIP	35271311
Intra	ATG13	O75143	ATG101	Homo sapiens	Q9BSB4	BioID	34524948
Intra	ATG13	O75143	ATG101	Homo sapiens	Q9BSB4	Crosslink	23392225
Intra	ATG13	O75143	MAP1LC3B	Homo sapiens	Q9GZQ8	Pull Down	20562859
Intra	ATG13	O75143	MAP1LC3B	Homo sapiens	Q9GZQ8	Pull Down	24290141
Intra	ATG13	O75143	MAP1LC3B	Homo sapiens	Q9GZQ8	SPR	24290141
Intra	ATG13	O75143	GABARAP	Homo sapiens	O95166	Y2H	24290141
Intra	ATG13	O75143	GABARAP	Homo sapiens	O95166	Pull Down	20562859
Intra	ATG13	O75143	OFD1	Homo sapiens	O75665	IF	33368531
Intra	ATG13	O75143	OFD1	Homo sapiens	O75665	Pull Down	33368531
Intra	ATG13	O75143	OFD1	Homo sapiens	O75665	Anti Bait CoIP	33368531
Intra	ATG13	O75143	GABARAPL2	Homo sapiens	P60520	Pull Down	20562859
Intra	ATG13	O75143	GABARAPL2	Homo sapiens	P60520	Anti Tag CoIP	35271311
Intra	ATG13	O75143	GABARAPL2	Homo sapiens	P60520	Y2H	21900206
Intra	ATG13	O75143	GABARAPL1	Homo sapiens	Q9H0R8	Pull Down	20562859
Intra	ATG13	O75143	ULK1	Homo sapiens	O75385	BioID	34524948
Intra	ATG13	O75143	ULK1	Homo sapiens	O75385	Crosslink	23392225
Intra	ATG13	O75143	ULK1	Homo sapiens	O75385	Anti Tag CoIP	23524951
Intra	ATG13	O75143	ULK1	Homo sapiens	O75385	Anti Tag CoIP	35271311
Intra	ATG13	O75143	ULK1	Homo sapiens	O75385	Anti Bait CoIP	19597335

Cross: Cross-species interaction Intra: Intraspecies interaction

ATG13 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P81905	ATG13 Antibody (YA1650)	WB, IP	Human, Mouse, Rat
HY-P81905A	ATG13 Antibody (YA1650)(PBS only)	WB, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Neurodegeneration With Brain Iron Accumulation	Nbia Neurodegeneration With Brain Iron Accumulation Disorders Neurodegeneration, With Brain Iron Accumulation
Liver Carcinoma In Situ	Carcinoma In Situ Of Liver And Biliary System Carcinoma In Situ Of Liver, Gallbladder And Bile Ducts
Charcot-Marie-Tooth Disease, Axonal, Type 2e	Charcot-Marie-Tooth Disease Type 2 CMT2E CMT2S CMT2Y Charcot-Marie-Tooth Disease Type 2e Charcot-Marie-Tooth Disease Type 2y Charcot-Marie-Tooth Disease Axonal Type 2s Charcot-Marie-Tooth Disease, Axonal, Type 2s Charcot-Marie-Tooth Disease, Type 2e Hereditary Motor And Sensory Neuropathy Type 2 Charcot-Marie-Tooth Neuropathy, Type 2s Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2s Charcot-Marie-Tooth Disease, Axonal, Type 2y Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2y Charcot-Marie-Tooth Neuropathy, Type 2y Charcot-Marie-Tooth Disease, Type 2y Autosomal Dominant Charcot-Marie-Tooth Disease Type 2e Charcot-Marie-Tooth Neuropathy Type 2e Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Vcp Mutation Cmt2 Due To Vcp Mutation Charcot-Marie-Tooth Disease Type 2s Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Autosomal Dominant Axonal Charcot-Marie-Tooth Disease Cmt2 Charcot-Marie-Tooth Neuropathy, Type 2e Hereditary Motor And Sensory Neuropathy Guadalajara Neuronal Type Hereditary Motor And Sensory Neuropathy Okinawa Type Autosomal Dominant Axonal Charcot-Marie-Tooth Type 2y Charcot-Marie-Tooth Neuropathy Type 2y Autosomal Recessive Axonal Charcot-Marie-Tooth Type 2s Charcot-Marie-Tooth Neuropathy Type 2s Charcot-Marie-Tooth Type 2 Autosomal Dominant Charcot-Marie-Tooth Disease Type 2y Charcot-Marie-Tooth Disease 2e Charcot-Marie-Tooth Disease Axonal Type 2e Charcot-Marie-Tooth Disease Neuronal Type 2e Charcot-Marie-Tooth Disease 2s Charcot-Marie-Tooth Neuropathy Axonal Type 2s Charcot-Marie-Tooth Disease 2y Charcot-Marie-Tooth Disease, Type 2 Hereditary Motor And Sensory-Neuropathy Type Ii
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-179089	SBP-1750	Inhibitor	98.05%	Unkown
HY-181699	ULK1-IN-5	Inhibitor	/	Unkown
HY-181815	SBP-5147		/	Unkown
HY-RS01141	ATG13 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ATG13	VGNC	VGNC:38217
Macaca mulatta	ATG13	VGNC	VGNC:70148
Bos taurus	ATG13	VGNC	VGNC:26251
Rattus norvegicus	ATG13	RGD	RGD:1310685
Felis catus	ATG13	VGNC	VGNC:59996
Mus musculus	ATG13	MGD	MGI:1196429
Others	ATG13	NCBI