Art. -Nr.: HY-129163

HJ-PI01

(Synonyms: 10-Acetylphenoxazine)

2 Cited Publications

Kundenbewertung

Based on 2 publication(s) in Google Scholar

HJ-PI01 (10-Acetylphenoxazine) is an orally active Pim-2 inhibitor. HJ-PI01 induces apoptosis and autophagic cell death of cancer cells. HJ-PI01 inhibits tumor growth in MDA-MB-231 xenograft mice. HJ-PI01 can be used for cancer research.

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Reinheit: 99.50%
CAS. Nr.: 6192-43-4
Formel: C₁₄H₁₁NO₂
Molecular Weight:225.24

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

HJ-PI01 Chemical Structure

CAS. Nr.: 6192-43-4

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Pim Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
K562	IC₅₀	>30 μM Compound: 13a	Cytotoxicity against human K562 cells assessed as cell growth inhibition after 48 hrs by Neubauer counting chamber analysis Cytotoxicity against human K562 cells assessed as cell growth inhibition after 48 hrs by Neubauer counting chamber analysis	[PMID: 26708110]
MDA-MB-231	IC₅₀	300 nM Compound: 63; HJ-PI01	Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay	[PMID: 33650861]

In Vitro

HJ-PI01 (0-3200 nmol/L; 48 hours) dose-dependently inhibits MDA-MB-231 cell growth and shows a substantial improvement compared with chlorpromazine and PI003^[1].
HJ-PI01 (100-400 nmol/L; 24 hours) shows weak toxicity to normal non-cancer cells^[1].
HJ-PI01 (300 nmol/L; 24 hours) induces autophagic cell death of MDA-MB-231 cells^[1].
HJ-PI01 (300 nmol/L; 24 hours) induces apoptotic cell death in MDA-MB-231 cells^[1].
HJ-PI01 (300 and 460 nmol/L; 12-48 hours) affects the expression levels of autophagy and apoptosis-related proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

MDA-MB-231 cell line
Concentration:

300 and 460 nmol/L
Incubation Time:

12, 24, 36 and 48 hours
Result:

Time-dependently increased LC3-II and Beclin-1 and induced p62 degradation in MDA-MB-231 cells. Increased the level of Bax. Decreased the level of Bcl-2, and Pim-2 and Pim-2 phosphorylation. Activated caspase-9 and caspase-3.

In Vivo

HJ-PI01 (40 mg/kg; oral administration, once daily for 10 days) inhibits tumor growth in MDA-MB-231 xenograft mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c female nude mice with MDA-MB-231 cells injection^[1]
Dosage:

40 mg/kg
Administration:

Oral administration; 40 mg/kg, once daily for 10 days
Result:

Significantly inhibited tumor growth with an obvious decreasing of the body, liver, spleen and kidney weights of the mice.

Chemical Information

CAS. Nr. 6192-43-4
Appearance Solid
Molecular Weight 225.24
Formel C₁₄H₁₁NO₂
Color White to off-white
SMILES

CC(N1C2=C(C=CC=C2)OC3=CC=CC=C13)=O
Synonyms

10-Acetylphenoxazine
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (2)

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Journal Impact Factor

Cell Mol Immunol

Targeting macrophage polarization by inhibiting Pim2 alleviates inflammatory arthritis via metabolic reprogramming. [Abstract]

2025 Apr;22(4):418-436. PMID: 40000906
Phytomedicine

Colchicine alleviates atherosclerosis combined with diabetes mellitus by targeting PIM2 and regulating the NF-κB signaling pathway. [Abstract]

2025 Nov:147:157194. PMID: 40865347

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 50 mg/mL (221.99 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.4397 mL

22.1985 mL

44.3971 mL

5 mM

0.8879 mL

4.4397 mL

8.8794 mL

10 mM

0.4440 mL

2.2199 mL

4.4397 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zhao YQ, et al. Characterization of HJ-PI01 as a novel Pim-2 inhibitor that induces apoptosis and autophagic cell death in triple-negative human breast cancer. Acta Pharmacol Sin. 2016 Sep;37(9):1237-50. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.4397 mL	22.1985 mL	44.3971 mL	110.9927 mL
	5 mM	0.8879 mL	4.4397 mL	8.8794 mL	22.1985 mL
	10 mM	0.4440 mL	2.2199 mL	4.4397 mL	11.0993 mL
	15 mM	0.2960 mL	1.4799 mL	2.9598 mL	7.3995 mL
	20 mM	0.2220 mL	1.1099 mL	2.2199 mL	5.5496 mL
	25 mM	0.1776 mL	0.8879 mL	1.7759 mL	4.4397 mL
	30 mM	0.1480 mL	0.7400 mL	1.4799 mL	3.6998 mL
	40 mM	0.1110 mL	0.5550 mL	1.1099 mL	2.7748 mL
	50 mM	0.0888 mL	0.4440 mL	0.8879 mL	2.2199 mL
	60 mM	0.0740 mL	0.3700 mL	0.7400 mL	1.8499 mL
	80 mM	0.0555 mL	0.2775 mL	0.5550 mL	1.3874 mL
	100 mM	0.0444 mL	0.2220 mL	0.4440 mL	1.1099 mL

Keywords

HJ-PI01

2 Cited Publications

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HJ-PI01

Epigenetics Compound Library

Immunology/Inflammation Compound Library

JAK/STAT Compound Library

Kinase Inhibitor Library

Anti-Cancer Compound Library

Orally Active Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Cancer Metabolism Compound Library

Anti-Obesity Compound Library

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Protein Kinase Compound Library

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Posttranslational Modification Library

Publications Citing Use of MedChemExpress (MCE) HJ-PI01

Alle Pim Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (2)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

HJ-PI01

Epigenetics Compound Library

Immunology/Inflammation Compound Library

JAK/STAT Compound Library

Kinase Inhibitor Library

Anti-Cancer Compound Library

Orally Active Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Cancer Metabolism Compound Library

Anti-Obesity Compound Library

Cancer Stem Cells Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Protein Kinase Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

Publications Citing Use of MedChemExpress (MCE) HJ-PI01

Alle Pim Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (2)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

HJ-PI01 Related Classifications

HY-129163 Related Classifications