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Art. -Nr.: HY-163083

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JN122

JN122, a spiroindoline-containing molecule, is a MDM2 inhibitor. JN122 Inhibits MDM2/p53 protein–protein interaction and exerts robust in vivo antitumor efficacy. JN122 has antiproliferative activity in HCT-116 cells and HEK-293 cells with IC₅₀ values of 39.6 nM and 4.28μM, respectively. JN122 can promote activation of p53 and its target genes, inhibited cell cycle progression, and induced cell apoptosis.

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CAS. Nr.: 3035577-19-3
Formel: C₃₃H₃₇Cl₂N₃O₄
Molecular Weight:610.57

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

JN122 Chemical Structure

CAS. Nr.: 3035577-19-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

IC50: 39.6 nM (HCT-116 cells); 4.28μM (HEK-293 cells)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	2.9 nM Compound: (-)60; JN122	Growth inhibition of human A549 cells harboring p53 incubated for 4 days by CCK-8 assay Growth inhibition of human A549 cells harboring p53 incubated for 4 days by CCK-8 assay	[PMID: 38062557]
HCT-116	IC₅₀	<1 nM Compound: (-)60; JN122	Antiproliferative activity against human HCT-116 cells harboring p53 assessed inhibition of cell growth incubated for 4 days by celltiter-glo assay Antiproliferative activity against human HCT-116 cells harboring p53 assessed inhibition of cell growth incubated for 4 days by celltiter-glo assay	[PMID: 38062557]
HCT-116	IC₅₀	13.6 nM Compound: XVI; JN122	Antiproliferative activity against human HCT-116 cells incubated for 4 days by CCK8 assay Antiproliferative activity against human HCT-116 cells incubated for 4 days by CCK8 assay	[PMID: 38581730]
HeLa	IC₅₀	12.24 nM Compound: (-)60; JN122	Growth inhibition of human HeLa cells harboring p53 incubated for 4 days by CCK-8 assay Growth inhibition of human HeLa cells harboring p53 incubated for 4 days by CCK-8 assay	[PMID: 38062557]
HepG2	IC₅₀	0.32 nM Compound: (-)60; JN122	Growth inhibition of human HepG2 cells harboring p53 incubated for 4 days by celltiter glo assay Growth inhibition of human HepG2 cells harboring p53 incubated for 4 days by celltiter glo assay	[PMID: 38062557]
MOLM-13	IC₅₀	49.9 nM Compound: (-)60; JN122	Growth inhibition of human MOLM-13 cells incubated for 2 days by CCK-8 assay Growth inhibition of human MOLM-13 cells incubated for 2 days by CCK-8 assay	[PMID: 38062557]
MOLM-13	IC₅₀	0.2 nM Compound: XVI; JN122	Antiproliferative activity against human MOLM-13 cells incubated for 2 days by CCK8 assay Antiproliferative activity against human MOLM-13 cells incubated for 2 days by CCK8 assay	[PMID: 38581730]
MSTO-211H	IC₅₀	9.48 nM Compound: (-)60; JN122	Growth inhibition of human MSTO-211H cells harboring p53 incubated for 4 days by CCK-8 assay Growth inhibition of human MSTO-211H cells harboring p53 incubated for 4 days by CCK-8 assay	[PMID: 38062557]
NCI-H460	IC₅₀	0.26 nM Compound: (-)60; JN122	Growth inhibition of human NCI-H460 cells harboring p53 incubated for 4 days by CCK-8 assay Growth inhibition of human NCI-H460 cells harboring p53 incubated for 4 days by CCK-8 assay	[PMID: 38062557]
SW480	IC₅₀	7.1 nM Compound: (-)60; JN122	Growth inhibition of human SW480 cells incubated for 4 days by CCK-8 assay Growth inhibition of human SW480 cells incubated for 4 days by CCK-8 assay	[PMID: 38062557]

Chemical Information

CAS. Nr. 3035577-19-3
Molecular Weight 610.57
Formel C₃₃H₃₇Cl₂N₃O₄
SMILES

CCN1[C@H]([C@@H]([C@@]2([C@@H]1CC(C)(C)C)CNC3=CC(Cl)=CC=C32)C4=CC(Cl)=CC=C4)C(NC5=CC=C(C=C5OC)C(O)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Cheng J, et al. Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein-Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy. J Med Chem. 2023 Dec 7. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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