KB05yne
Based on 1 Customer Validation
KB05yne is a site-selective, alkyne-functionalized electrophilic "probe" fragment probe designed for covalent ligand discovery, with preferential reactivity toward specific cysteine residues in proteins. KB05yne strongly labels wild-type target proteins (e.g., CDKN2AIP, HPCAL1) but does not label their cysteine-to-alanine mutants, confirming site-specific cysteine reactivity. KB05yne can be used for the discovery and optimization of site-specific covalent ligands, and is applicable to proteins with diverse structures and functions, especially in studies targeting cysteine residues in cancer-related or difficult-to-purify proteins.
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- Reinheit: 99.97%
- CAS. Nr.: 2724919-69-9
- Formel: C22H21BrN2O2
- Molecular Weight:425.32
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Speicherung:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
KB05yne exhibits preferential reactivity toward specific cysteine residues in proteins, and strongly labels wild-type target proteins (e.g., CDKN2AIP, HPCAL1)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2724919-69-9
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Appearance Oil
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Molecular Weight 425.32
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Formel C22H21BrN2O2
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Color Colorless to light yellow
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SMILES
O=C(NCCCCC#C)C1=CC=C(N(C2=CC=C(Br)C=C2)C(C=C)=O)C=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (235.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3512 mL | 11.7559 mL | 23.5117 mL | 58.7793 mL |
| 5 mM | 0.4702 mL | 2.3512 mL | 4.7023 mL | 11.7559 mL | |
| 10 mM | 0.2351 mL | 1.1756 mL | 2.3512 mL | 5.8779 mL | |
| 15 mM | 0.1567 mL | 0.7837 mL | 1.5674 mL | 3.9186 mL | |
| 20 mM | 0.1176 mL | 0.5878 mL | 1.1756 mL | 2.9390 mL | |
| 25 mM | 0.0940 mL | 0.4702 mL | 0.9405 mL | 2.3512 mL | |
| 30 mM | 0.0784 mL | 0.3919 mL | 0.7837 mL | 1.9593 mL | |
| 40 mM | 0.0588 mL | 0.2939 mL | 0.5878 mL | 1.4695 mL | |
| 50 mM | 0.0470 mL | 0.2351 mL | 0.4702 mL | 1.1756 mL | |
| 60 mM | 0.0392 mL | 0.1959 mL | 0.3919 mL | 0.9797 mL | |
| 80 mM | 0.0294 mL | 0.1469 mL | 0.2939 mL | 0.7347 mL | |
| 100 mM | 0.0235 mL | 0.1176 mL | 0.2351 mL | 0.5878 mL |
KB05yne Related Classifications
HY-177554 Related Classifications
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