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Art. -Nr.: HY-123761

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L505-yne

L505-yne is an active site-directed γ-secretase inhibitor. L505-yne blocks photoaffinity labeling of PS1-NTF, PS1-CTF, and SPP by clickable GSI photoprobes, binds the γ-secretase complex and inhibits Aβ42 production. L458-BPyne can be used for the research of Alzheimer’s disease.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 1374647-07-0
Formel: C₅₂H₆₄N₄O₇
Molecular Weight:857.11

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

L505-yne Chemical Structure

CAS. Nr.: 1374647-07-0

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

L505-yne (Compound 5) potently inhibits γ-secretase-mediated Aβ42 production in cell-free HeLa membranes (IC₅₀ = 0.3 nM) and in CHO-APP cells (IC₅₀ = 36 nM)^[1].
L505-yne (20 nM; 1 h) prefers for PS1-CTF with minimal PS1-NTF labeling, but also revealed significant labeling of SPP^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1374647-07-0
Molecular Weight 857.11
Formel C₅₂H₆₄N₄O₇
SMILES

[C@@H](CC1=CC=CC=C1)(C[C@H]([C@H](CC2=CC=CC=C2)NC(OC(C)(C)C)=O)O)C(N[C@H](C(N[C@@H](CC3=CC=C(C(=O)C4=CC=CC=C4)C=C3)C(NCCCCC#C)=O)=O)CC(C)C)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Crump CJ, et al. Development of clickable active site-directed photoaffinity probes for γ-secretase. Bioorg Med Chem Lett. 2012;22(8):2997-3000. [Content Brief]

[2]. Ballard TE, et al. Investigating γ-secretase protein interactions in live cells using active site-directed clickable dual-photoaffinity probesMed. Chem. Commun. 2013 Nov 04;5:321-327.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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