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Lorukafusp alfa

(Synonyms: APN-301; hu14.18-IL2; EMD 273063)
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Lorukafusp alfa (14.18 mAb; hu14.18-IL2) is an immunocytokine consisting of the humanized 14.18 anti-GD2 mAb linked to IL210. Lorukafusp alfa has activity mediated by activation of antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity via the binding of hu14.18-IL2 to GD2 on the tumor cell surface, followed by binding to Fc receptors on effector cells along with activation of NK and T cells via IL2 receptor binding. Lorukafusp alfa has anti-tumor activity.

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  • Reinheit : 97.8%
  • CAS. Nr.: 2131168-99-3
  • Molecular Weight:175.6 kDa
  • Speicherung:
    Shipping with dry ice

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Lorukafusp alfa
  • Experimental Validation Results for Lorukafusp alfa
  • Experimental Validation Results for Lorukafusp alfa
  • Lorukafusp alfa Chemical Structure
    Lorukafusp alfa Chemical Structure
CAS. Nr.: 2131168-99-3
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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Finden Sie Ihren Händler vor Ort Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Immobilized Human IL-2R-alpha/CD25 Protein (HEK293, C-His, HY-P70628) can bind Lorukafusp alfa. The EC50 for this effect is 5.85 ng/mL.

  • 1/16

    Immobilized Ganglioside GD2 (HY-165740) can bind Lorukafusp alfa. The EC50 for this effect is 365.7 ng/mL.

  • Lorukafusp alfa Chemical Structure
    1/16
  • Lorukafusp alfa
  • Immobilized Human IL-2R-alpha/CD25 Protein (HEK293, C-His, HY-P70628) can bind Lorukafusp alfa. The EC50 for this effect is 5.85 ng/mL.
  • Immobilized Ganglioside GD2 (HY-165740) can bind Lorukafusp alfa. The EC50 for this effect is 365.7 ng/mL.