Art. -Nr.: HY-W187305

MASM7

5 Cited Publications

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Based on 5 publication(s) in Google Scholar

MASM7 is a mitofusin activator, and can achieve mitochondrial fusion via mitofusins. MASM7 can increase Mito AR with an EC₅₀ value of 75 nM in MEFs in concentration-responsively, and can promote mitochondrial fusion by directly activating MFN2 or MFN. MASM7 also demonstrates direct binding to the HR2 domain of MFN2 with K_d value of 1.1 μM.

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Reinheit: 99.85%
CAS. Nr.: 920868-45-7
Formel: C₂₂H₂₃N₅O₂S₂
Molecular Weight:453.58

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

MASM7 Chemical Structure

CAS. Nr.: 920868-45-7

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Publications (5)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

MASM7 (1-10 μM, 2 h) increases Mito AR with an EC₅₀ value of 75 nM in MEFs in concentration-responsively, and can promote mitochondrial fusion by directly activating MFN2 or MFN^[1].
MASM7 (1-1000 μM, 5 min) demonstrates direct binding to the HR2 domain of MFN2 with K_d value of 1.1 μM^[1].
MASM7 (1 μM, 6 h) does not induce DNA damage in any of the cell lines^[1].
MASM7 (0-1.5 μM, 72 h) does not decrease cellular viability over the course of 72 h^[1].
MASM7 (1 μΜ, 6 h) does not induce caspase-3/7 activation in U2OS cells^[1].
MASM7 (0-1 μM, 6 h) increases mitochondrial membrane potential in WT MEFs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 920868-45-7
Appearance Solid
Molecular Weight 453.58
Formel C₂₂H₂₃N₅O₂S₂
Color White to yellow
SMILES

O=C(N)C1=C(SC2=C1CCC2)NC(C(C)SC3=NN=C(C4CC4)N3C5=CC=CC=C5)=O
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (5)

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Journal Impact Factor

Adv Compos Hybrid Mater

2025 Feb 04.
Cell Prolif

Targeting ROCK1/YAP1 Axis Ameliorates Inflammation-Induced Prostatic Hyperplasia via Stabilising SIRT1-Dependent Mitochondrial Dynamics. [Abstract]

2025 Jul 4:e70085. PMID: 40616266

MASM7 purchased from MedChemExpress. Usage Cited in: Cell Prolif. 2025 Jul 4:e70085. [Abstract]

The MFN2 agonist MASM7 (2 μM) significantly impeded the proliferative processes of BPH-1 cells elicited by LPS, manifested as reduced proportions of EdU‐positive proliferative cells.

MASM7 purchased from MedChemExpress. Usage Cited in: Cell Prolif. 2025 Jul 4:e70085. [Abstract]

The MFN2 agonist MASM7 (2 μM) reversed the LPS-triggered EMT switch in BPH-1 cells, characterised by the restoration of E-cadherin and the loss of vimentin.
CNS Neurosci Ther

Downregulation of Mfn2 Contributes to Chronic Postsurgical Pain via Inducing the Pyroptosis of GABAergic Neurons in the Spinal Cord. [Abstract]

2025 Jul;31(7):e70508. PMID: 40631358

MASM7 purchased from MedChemExpress. Usage Cited in: CNS Neurosci Ther. 2025 Jul;31(7):e70508. [Abstract]

MASM7 (10 μg/10 μL; i.t.; once daily for 7 d) reduced the mRNA expression of IL‐1β and IL‐18 in skin/muscle incision and retraction (SMIR) rats compared with vehicle.

MASM7 purchased from MedChemExpress. Usage Cited in: CNS Neurosci Ther. 2025 Jul;31(7):e70508. [Abstract]

MASM7 (10 μg/10 μL; i.t.; once daily for 7 d) decreased the expression of NLRP3, caspase-1, P20, P10, GSDMD, and GSDMD-N in skin/muscle incision and retraction (SMIR) rats.

MASM7 purchased from MedChemExpress. Usage Cited in: CNS Neurosci Ther. 2025 Jul;31(7):e70508. [Abstract]

MASM7 (10 μg/10 μL; i.t.; once daily for 7 d) treatment alleviated the mitochondrial morphological injury in spinal neurons of skin/muscle incision and retraction (SMIR) rats. The labeled red boxes highlighted the mitochondrial ultrastructure. The red arrow represented the mitochondria.
Biomol Biomed

Forkhead box O-1 regulates the biological behavior of BMP-2-induced human bone mesenchymal stem cells through mitochondrial dynamics and autophagy. [Abstract]

2025 Mar 7;25(4):869-882. PMID: 39226107
SSRN

2025 Jun 3.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (220.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.2047 mL

11.0234 mL

22.0468 mL

5 mM

0.4409 mL

2.2047 mL

4.4094 mL

10 mM

0.2205 mL

1.1023 mL

2.2047 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (5.51 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (4.59 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Emmanouil Zacharioudakis, et al. Modulating mitofusins to control mitochondrial function and signaling. Nat Commun. 2022 Jul 7;13(1):3775. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.2047 mL	11.0234 mL	22.0468 mL	55.1171 mL
	5 mM	0.4409 mL	2.2047 mL	4.4094 mL	11.0234 mL
	10 mM	0.2205 mL	1.1023 mL	2.2047 mL	5.5117 mL
	15 mM	0.1470 mL	0.7349 mL	1.4698 mL	3.6745 mL
	20 mM	0.1102 mL	0.5512 mL	1.1023 mL	2.7559 mL
	25 mM	0.0882 mL	0.4409 mL	0.8819 mL	2.2047 mL
	30 mM	0.0735 mL	0.3674 mL	0.7349 mL	1.8372 mL
	40 mM	0.0551 mL	0.2756 mL	0.5512 mL	1.3779 mL
	50 mM	0.0441 mL	0.2205 mL	0.4409 mL	1.1023 mL
	60 mM	0.0367 mL	0.1837 mL	0.3674 mL	0.9186 mL
	80 mM	0.0276 mL	0.1378 mL	0.2756 mL	0.6890 mL
	100 mM	0.0220 mL	0.1102 mL	0.2205 mL	0.5512 mL

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MASM7

Publications Citing Use of MedChemExpress (MCE) MASM7

Biologische Aktivität

Chemical Information

Publications (5)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

MASM7 Related Classifications

Art. -Nr.: HY-W187305