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Art. -Nr.: HY-124885

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MD 220661

MD 220661 is a semicarbazide-sensitive amine oxidase (SSAO) and monoamine oxidase (MAO) inhibitor, and serves as a major metabolite of MD 240928 in rat brain. MD 220661 acts as a substrate for SSAO and exhibits reversible, selective MAO-B inhibition in rat tissues; in the absence of semicarbazide, its inhibitory potency against MAO-A activity decreases with prolonged pre-incubation time. MD 220661 is applicable to studies related to enzyme-catalyzed metabolism.

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CAS. Nr.: 73423-35-5
Formel: C₁₇H₁₇ClN₂O₃
Molecular Weight:332.78

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Please store the product under the recommended conditions in the Certificate of Analysis.

MD 220661 Chemical Structure

CAS. Nr.: 73423-35-5

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- In Vitro
- In Vivo
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Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

MAO-A

MAO-B

Alle Monoamine Oxidase Isoform-spezifische Produkte anzeigen :

MAO-A
MAO-B

In Vitro

MD 220661 inhibits semicarbazide-sensitive amine oxidase in rat aorta homogenates with an initial IC₅₀ of 3.0 μM, but its inhibitory potency decreases significantly with preincubation time, indicating it acts as both an inhibitor and substrate of the enzyme^[1].
MD 220661 inhibits semicarbazide-sensitive amine oxidase in rat heart homogenates with an initial IC₅₀ of 1.9 μM, and its inhibitory potency decreases with preincubation time, consistent with it acting as both an inhibitor and substrate of the enzyme^[1].
MD 220661 inhibits monoamine oxidase A in rat aorta homogenates, and its inhibitory potency decreases significantly with preincubation time in the absence of semicarbazide, but only slightly in the presence of semicarbazide^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MD 220661 (10-50 mg/kg; i.v.; single dose) does not produce significant inhibition of rat heart SSAO activity when measured 15 minutes post-administration^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 73423-35-5
Molecular Weight 332.78
Formel C₁₇H₁₇ClN₂O₃
SMILES

O=C1OC(CN1C2=CC=C(C=C2)OCC3=CC=CC(Cl)=C3)CN
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Dostert P, et al. Inhibition of semicarbazide-sensitive amine oxidase by monoamine oxidase B inhibitors from the oxazolidinone series. The Journal of pharmacy and pharmacology. 1984 Nov;36(11):782-5. [Content Brief]

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Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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- In Vitro
- In Vivo
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MD 220661

Alle Monoamine Oxidase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

MD 220661 Related Classifications

HY-124885 Related Classifications