Nec-34i
Nec-34i is an inactive analog structurally similar to Nec-34 (HY-132203). Nec-34i has no effect on RIPK1 kinase activity and cannot inhibit necroptosis.
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- CAS. Nr.: 2212541-00-7
- Formel: C21H19N3O2S
- Molecular Weight:377.46
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Nec-34i (20 μM; 1 h) does not bind to or stabilize recombinant human RIPK1 kinase domain (residues 1-330) in a protein thermal shift assay[1].
Nec-34i (20 μM; 10 min) does not inhibit the in vitro kinase activity of human RIPK1 kinase domain (residues 1-330) from transfected 293T cells[1].
Nec-34i (10 μM) does not inhibit TNFα-induced necroptosis in FADD-deficient Jurkat cells or zVAD.fmk-induced necroptosis in L929 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2212541-00-7
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Molecular Weight 377.46
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Formel C21H19N3O2S
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SMILES
N#CC1=C(NC(CC1C2=CC=C(C)C=C2)=O)SCC(NC3=CC=CC=C3)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Nec-34i Related Classifications
HY-W674387 Related Classifications
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