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Art. -Nr.: HY-P3440A

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NOTA-WL12

NOTA-WL12 is a peptide-based imaging probe targeting PD-L1. NOTA-WL12 is a PD-L1 inhibitory peptide derivative and also a NOTA-conjugated WL12 precursor used for ⁶⁸Ga radiolabeling. The binding of NOTA-WL12 to human and mouse PD-L1 is evaluated by surface plasmon resonance. NOTA-WL12 is predicted by computational docking to interact with PD-L1.

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CAS. Nr.: 2767203-39-2
Formel: C₁₁₁H₁₅₄N₂₆O₂₆S₂
Molecular Weight:2332.70

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

NOTA-WL12 Chemical Structure

CAS. Nr.: 2767203-39-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
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Biologische Aktivität

Beschreibung

In Vitro

NOTA-WL12 (1 mg/mL; 15 min) is radiolabeled to [¹⁸F]AlF-NOTA-WL12 with a yield of 29% and a radiochemical purity of 97.3%^[2].
NOTA-WL12 (50 µg; 15 min) is radiolabeled with ⁶⁸Ga at 90°C, yielding ⁶⁸Ga-WL12 with a radiochemical purity of > 99% as determined by HPLC^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2767203-39-2
Molecular Weight 2332.70
Formel C₁₁₁H₁₅₄N₂₆O₂₆S₂
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Yang Zhang, et al. PET Imaging of Peptide Probe Al[18F]F-NOTA-PCP1 for Monitoring the Engagement of PD-L1 Antibodies in Tumors. Mol. Pharmaceutics 4 March 2024; 21 (3): 1515-1525.

[2]. Ferro-Flores G, et al. Synthesis and Evaluation of [18F]AlF-NOTA-iPD-L1 as a Potential Theranostic Pair for [177Lu]Lu-DOTA-iPD-L1. Pharmaceutics. 2025 Jul 16;17(7):920. [Content Brief]

[3]. Li D, et al. Construction of an Iodine-Labeled CS1001 Antibody for Targeting PD-L1 Detection and Comparison with Low-Molecular-Peptide Micro-PET Imaging. Molecular pharmaceutics. 2022 Nov 07;19(11):4382-4389. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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