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Art. -Nr.: HY-189374

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OAT-IN-2

OAT-IN-2 is an ornithine aminotransferase (hOAT) inhibitor. OAT-IN-2 is used in the research of hepatocellular carcinoma.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 3057206-96-6
Formel: C₇H₉F₂NO₂
Molecular Weight:177.15

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

OAT-IN-2 Chemical Structure

CAS. Nr.: 3057206-96-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Protokoll (1)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

OAT-IN-2 is an ornithine aminotransferase (hOAT) inhibitor. OAT-IN-2 is used in the research of hepatocellular carcinoma^[1].

In Vitro

OAT-IN-2 (Compound 5) is a time-dependent inhibitor of hOAT with a k_inact/K_I of 0.219 mM^-1 min^-1^[1].
OAT-IN-2 (2-18 equiv; 72 h) irreversibly inhibits hOAT, as no enzymatic activity was recovered after 72 h of dialysis^[1].
OAT-IN-2 forms a noncovalent, tight-binding adduct with hOAT^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS. Nr. 3057206-96-6
Molecular Weight 177.15
Formel C₇H₉F₂NO₂
SMILES

O=C([C@]12C[C@H](N)C[C@@]1([H])C2(F)F)O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Protokoll

All Animals and Diseases

Liver Cancer Modeling
Liver cancer can be classified into primary liver cancer and secondary liver cancer. Secondary liver cancer is the metastatic liver cancer. Primary liver cancer includes hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC) and fibrolamellar HCC, of which HCC is the most common form, accounting for approximately 90% of primary liver cancers^[1]. HCC mouse models include chemical agent-induced models, transplanted tumor models, and genetic engineered models.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Devitt AN, et al. Design and Elucidation of a Strain-Relief-Driven Ring Opening Mechanism of Inactivation of Ornithine Aminotransferase by (1S,3R,5R)-3-Amino-6,6-difluorobicyclo[3.1.0]hexane-1-carboxylic Acid. J Am Chem Soc. 2026 Aug 19;148(32):34916-34927.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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