Art. -Nr.: HY-154954

Ogremorphin

(Synonyms: OGM; GPR68-IN-1; OGM-8345)

2 Cited Publications

Kundenbewertung

Based on 2 publication(s) in Google Scholar

Ogremorphin (OGM) is a G protein coupled sensor GPR68 inhibitor with anti-inflammatory and anti-tumor activities. Ogremorphin can inhibit the migration of human melanoma cells and induce ferroptosis in glioblastoma cells.

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Reinheit: 99.13%
CAS. Nr.: 352563-21-4
Formel: C₂₁H₁₇N₃OS
Molecular Weight:359.44

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Ogremorphin Chemical Structure

CAS. Nr.: 352563-21-4

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Publications Citing Use of MedChemExpress (MCE) Ogremorphin

Customer Validation & Images

Cell Proliferation/Viability AssayELISACell Imaging/StainingHistological Imaging/Staining

Cell Proliferation/Viability Assay
ELISA
Cell Imaging/Staining
Histological Imaging/Staining

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (2)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

GPR68^[1].

In Vitro

Ogremorphin (1-5 µM) can reduce the release of inflammatory factors induced by lipopolysaccharide or acidosis in human pulmonary artery endothelial cells, and inhibit inflammatory responses^[1].
Ogremorphin (5 µM, 5 days) can inhibit the migration of human melanoma WM-115 cells^[2].
Ogremorphin (0-100 µM, 72 h) can induce ferroptosis and inhibit tumor cell viability in glioblastoma U87 cells by promoting the expression of iron death related markers and mediators^[3].
Ogremorphin (0-100 µM) can reduce the survival rate of patient derived cell lines (PDX and neurospheres), with LC₅₀ value of 0.42-2.7 µM^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[3].

Cell Line:

U87 and U138 cell lines
Concentration:

0-100 µM
Incubation Time:

72 h
Result:

Reduced the vitality of glioblastoma cells.

RT-PCR^[1].

Cell Line:

Human pulmonary arterial endothelial cells (HPAECs)
Concentration:

1-5 µM
Incubation Time:
Result:

Reduced the upregulation of inflammatory cytokine/chemokine genes TNF - α, ICAM-1, VCAM-1, IL-6, IL-8, IL-1 β, and CXCL5.

Cell Migration Assay ^[2].

Cell Line:

WM115, A2050 and MEWO cell lines
Concentration:

5 µM
Incubation Time:

5 days
Result:

Inhibited migration in WM115, A2050 and MEWO cell lines.

In Vivo

Ogremorphin can alleviate vascular leakage, pulmonary inflammation, and pulmonary endothelial dysfunction caused by intratracheal injection of LPS or acidosis in mice^[1].
Ogremorphin (10 μM) can cause abnormal melanocyte pigmentation and developmental disorders in zebrafish embryos^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Zebrafish^[3].
Dosage:

10 μM
Administration:

Added to a 96 well microtiter plate (5 embryos/well) arranged with zebrafish fertilized eggs
Result:

Induced phenotypes encompassing a wavy notochord, abnormal pigmentation, craniofacial defects, ventral curvature, and a shortened body axis.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 352563-21-4
Appearance Solid
Molecular Weight 359.44
Formel C₂₁H₁₇N₃OS
Color Yellow to orange
SMILES

O=C1NC2=CC=C(CC)C=C2C13SC(C4=C5C=CC=CC5=CC=C4)=NN3
Synonyms

OGM; GPR68-IN-1; OGM-8345
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (2)

All Cell Proliferation/Viability AssayELISACell Imaging/StainingHistological Imaging/Staining

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Journal Impact Factor

Inflammation

Pharmacological Activation of GPR68 Attenuates Ferroptosis in Spinal Cord Ischemia/Reperfusion Injury Through PI3K/Akt-Mediated Nrf2 Antioxidant Pathway. [Abstract]

2025 Jun 18. PMID: 40528120
Biology (Basel)

Targeting GPR68 Alleviates Inflammation and Lipid Accumulation in Metabolic Dysfunction-Associated Steatohepatitis. [Abstract]

2026 Jan 26;15(3):233. PMID: 41677704

Ogremorphin purchased from MedChemExpress. Usage Cited in: Biology (Basel). 2026 Jan 26;15(3):233. [Abstract]

HepG2 cell viability after Ogremorphin (OGM) (1, 2.5 5, 10 μM) treatment.

Ogremorphin purchased from MedChemExpress. Usage Cited in: Biology (Basel). 2026 Jan 26;15(3):233. [Abstract]

HepG2 cells pretreated with OA/PA were treated with different concentrations of Ogremorphin (OGM) (1, 2.5 μM) or vehicle for 24 h, and IL-6 levels in the cell culture supernatant were measured.

Ogremorphin purchased from MedChemExpress. Usage Cited in: Biology (Basel). 2026 Jan 26;15(3):233. [Abstract]

HepG2 cells were co-treated with OA/PA (2:1, 750 μM) and 2.5 μM Ogremorphin (OGM) (2.5 μM) or vehicle (Veh) at 0, 6, 12, and 24 h. Representative images of Oil Red O staining.

Ogremorphin purchased from MedChemExpress. Usage Cited in: Biology (Basel). 2026 Jan 26;15(3):233. [Abstract]

Representative H&E and Oil Red O staining of mouse liver tissue treated with Ogremorphin (OGM) (30 mg/kg).

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 50 mg/mL (139.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.7821 mL

13.9105 mL

27.8211 mL

5 mM

0.5564 mL

2.7821 mL

5.5642 mL

10 mM

0.2782 mL

1.3911 mL

2.7821 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: 1.25 mg/mL (3.48 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 1.25 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (285 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Karki P, et al. A Novel Group of Ogremorphin Inhibitors Targeting G Protein-coupled Sensor GPR68 Rescue Lipopolysaccharide or Acidosis-induced Lung Endothelial Dysfunction[M]//C108. MECHANISMS OF LUNG INFLAMMATION AND INFECTION. American Thoracic Society, 2024: A6846-A6846.

[2]. Williams C H, et al. Coupling Metastasis to pH-Sensing GPR68 Using a Novel Small Molecule Inhibitor[J]. BioRxiv, 2019: 612549.

[3]. Williams C H, et al. GPR68-ATF4 signaling is a novel prosurvival pathway in glioblastoma activated by acidic extracellular microenvironment. Exp Hematol Oncol. 2024 Jan 31;13(1):13. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.7821 mL	13.9105 mL	27.8211 mL	69.5526 mL
	5 mM	0.5564 mL	2.7821 mL	5.5642 mL	13.9105 mL
	10 mM	0.2782 mL	1.3911 mL	2.7821 mL	6.9553 mL
	15 mM	0.1855 mL	0.9274 mL	1.8547 mL	4.6368 mL
	20 mM	0.1391 mL	0.6955 mL	1.3911 mL	3.4776 mL
	25 mM	0.1113 mL	0.5564 mL	1.1128 mL	2.7821 mL
	30 mM	0.0927 mL	0.4637 mL	0.9274 mL	2.3184 mL
	40 mM	0.0696 mL	0.3478 mL	0.6955 mL	1.7388 mL
	50 mM	0.0556 mL	0.2782 mL	0.5564 mL	1.3911 mL
	60 mM	0.0464 mL	0.2318 mL	0.4637 mL	1.1592 mL
	80 mM	0.0348 mL	0.1739 mL	0.3478 mL	0.8694 mL
	100 mM	0.0278 mL	0.1391 mL	0.2782 mL	0.6955 mL

Keywords

Ogremorphin

2 Cited Publications

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Ogremorphin

Publications Citing Use of MedChemExpress (MCE) Ogremorphin

Biologische Aktivität

Chemical Information

Publications (2)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Ogremorphin Related Classifications

HY-154954 Related Classifications