country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-145232

Copy Link Print Information

PhosTAC7

(Synonyms: OGTAC-3)

4 Cited Publications

Kundenbewertung

Based on 4 publication(s) in Google Scholar

PhosTAC7 is a heterobifunctional molecule named as a Phosphorylation Targeting Chimera (PhosTAC). PhosTAC7 can dephosphorylate the PDCD4 protein, FOXO3a protein, and tau protein by recruiting serine/threonine protein phosphatase 2A (PP2A). PhosTAC7 offers the advantage of selectively modulating the phosphorylation state of individual target proteins, making it a promising tool for research in cancer and tau protein-related neurodegenerative diseases (Alzheimer's disease).

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 99.23%
CAS. Nr.: 3016307-75-5
Formel: C₅₈H₈₇ClN₂O₁₇
Molecular Weight:1119.77

Speicherung:

Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

PhosTAC7 Chemical Structure

CAS. Nr.: 3016307-75-5

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Publications (4)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

PhosTAC7 (1-5 μM, 24 h) mediates ternary complex formation between Halo-PDCD4/tau and FKBP12(F36V)-PP2A A in HeLa cells^[1]^[2].
PhosTAC7 (0.25-10 μM, 2-24 h) effectively induces the dephosphorylation of PDCD4/tau, and can simultaneously regulate multiple phosphorylation sites, with dose and time dependence in Hela cells^[1]^[2].
PhosTAC7 (5-10 μM, 3-8 h) alters the phosphorylation kinetics of FOXO3a and resists the stimulation of growth factors depending on the activity of the PP2A phosphatase in Hela cells^[1].
PhosTAC7 (0.5 μM, 24 h+ washout 24-48 h) still maintains a significant dephosphorylation effect even after the replacement of the fresh culture medium in Hela cells^[2].
PhosTAC7 (1 μM, 1-3 d) indirectly accelerates tau degradation by promoting dephosphorylation in Hela cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Wild-type HeLa cells and Halo-PDCD4/ FKBP12(F36V)-PP2A A P179R-mutant HeLa cells
Concentration:

1, 5 and 10 μM
Incubation Time:

2, 4, 8, 12, 16 and 24 h
Result:

Dose and time-dependently induced dephosphorylation at the Ser67 site of PDCD4 in wild cells.
Completely lost its ability to phosphorylate in the P179R mutant cell line.

Western Blot Analysis^[1]

Cell Line:

Wild-type HeLa cells
Concentration:

5 μM
Incubation Time:

Pretreated 3 h and stimulated by EGF for 0, 30, 60, 120, 180 and 300 min
Result:

Maintained the basal phosphorylation level and resisted EGF stimulation.

Western Blot Analysis^[2]

Cell Line:

HeLa cells
Concentration:

0.25, 0.5, 1 and 10 μM
Incubation Time:

24 h
Result:

Effectively and specifically induced Tau dephosphorylation, and depended on the functional PP2A holoenzyme.

Chemical Information

CAS. Nr. 3016307-75-5
Appearance Oil
Molecular Weight 1119.77
Formel C₅₈H₈₇ClN₂O₁₇
Color Colorless to light yellow
SMILES

CC[C@@H](C1=CC(OC)=C(C(OC)=C1)OC)C(N2CCCC[C@H]2C(O[C@@H](C3=CC(OCC(NCCOCCOCCOCCOCCOCCOCCOCCCCCCCl)=O)=CC=C3)CCC4=CC(OC)=C(C=C4)OC)=O)=O
Synonyms

OGTAC-3
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (4)

All

Sort by:

Journal Impact Factor

Phytomedicine

Berbamine alleviates neuropathic pain via suppressing spinal TMEM34/SGK1/FOXO3 axis. [Abstract]

2025 May:140:156619. PMID: 40088745
Cell Genom

Pooled endogenous protein tagging and recruitment for systematic profiling of protein function. [Abstract]

2024 Sep 4:100651. PMID: 39255790
bioRxiv

2026 Mar 18.
Res Sq

2025 Mar 24.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (89.30 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

0.8930 mL

4.4652 mL

8.9304 mL

5 mM

0.1786 mL

0.8930 mL

1.7861 mL

10 mM

0.0893 mL

0.4465 mL

0.8930 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Chen PH, et al. Modulation of Phosphoprotein Activity by Phosphorylation Targeting Chimeras (PhosTACs). ACS Chem. Biol. 2021 Nov 15.

[2]. Hu Z, et al. Targeted Dephosphorylation of Tau by Phosphorylation Targeting Chimeras (PhosTACs) as a Therapeutic Modality. J Am Chem Soc. 2023 Feb 8. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	0.8930 mL	4.4652 mL	8.9304 mL	22.3260 mL
	5 mM	0.1786 mL	0.8930 mL	1.7861 mL	4.4652 mL
	10 mM	0.0893 mL	0.4465 mL	0.8930 mL	2.2326 mL
	15 mM	0.0595 mL	0.2977 mL	0.5954 mL	1.4884 mL
	20 mM	0.0447 mL	0.2233 mL	0.4465 mL	1.1163 mL
	25 mM	0.0357 mL	0.1786 mL	0.3572 mL	0.8930 mL
	30 mM	0.0298 mL	0.1488 mL	0.2977 mL	0.7442 mL
	40 mM	0.0223 mL	0.1116 mL	0.2233 mL	0.5582 mL
	50 mM	0.0179 mL	0.0893 mL	0.1786 mL	0.4465 mL
	60 mM	0.0149 mL	0.0744 mL	0.1488 mL	0.3721 mL
	80 mM	0.0112 mL	0.0558 mL	0.1116 mL	0.2791 mL

Keywords

PhosTAC7

4 Cited Publications

100 mg Angebot einholen

Subscribe to the

MedChemExpress

Newsletter

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen

Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Publications (4)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

PhosTAC7

Publications Citing Use of MedChemExpress (MCE) PhosTAC7

Biologische Aktivität

Chemical Information

Publications (4)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

PhosTAC7 Related Classifications

HY-145232 Related Classifications