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Plaunotol

(Synonyms: CS-684)

Plaunotol is an orally active acyclic diterpene alcohol. Plaunotol has antibacterial activity against Helicobacter pylori which causes peptic ulcer . Plaunotol inhibits tumor angiogenesis and cell proliferation. Plaunotol induces apoptosis by activation of caspase 8 and caspase 9 pathways. Plaunotol is a potential anticancer agent against colon cancer .

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CAS. Nr.: 64218-02-6
Formel: C₂₀H₃₄O₂
Molecular Weight:306.48

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Plaunotol Chemical Structure

CAS. Nr.: 64218-02-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Plaunotol is an orally active acyclic diterpene alcohol. Plaunotol has antibacterial activity against Helicobacter pylori which causes peptic ulcer ^[1]. Plaunotol inhibits tumor angiogenesis and cell proliferation. Plaunotol induces apoptosis by activation of caspase 8 and caspase 9 pathways. Plaunotol is a potential anticancer agent against colon cancer ^[2].

In Vitro

Plaunotol (0, 10, 20, or 40 μM, 24 or 48 h) shows a significant inhibition of cell proliferation in human colon cancer cell line DLD1^[2].
Plaunotol (40 μM, 24 or 48 h) induces apoptosis in human colon cancer cell line DLD1^[2].
Plaunotol (0, 10, 20, or 40 μM, 48 h) causes activation of caspase-3 in human colon cancer cell line DLD1^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[2]

Cell Line:

human colon cancer cell line DLD1
Concentration:

0, 10, 20, or 40 μM
Incubation Time:

24 or 48 h
Result:

Inhibited the proliferation of human colon cancer cell line DLD1 after 48 h.

Apoptosis Analysis^[2]

Cell Line:

human colon cancer cell line DLD1
Concentration:

40 μM
Incubation Time:

24 or 48 h
Result:

Caused a significant increase in the population of Annexin V ^[+] apoptotic cells.

Western Blot Analysis^[2]

Cell Line:

human colon cancer cell line DLD1
Concentration:

40 μM
Incubation Time:

48 h
Result:

Induced PARP cleavage, and showed activation of caspase-3.

In Vivo

Plaunotol (10, 25 or 50 mg/kg, orally, for 3 h) significantly alleviates gastric mucosal damage in male Wistar rats treated with C48/80 ^[3].
Plaunotol (10, 25 or 50 mg/kg, orally, for 3 h) does not affect serum serotonin and histamine concentrations or gastric mucosal blood flow in male Wistar rats treated with C48/80 ^[3].
Plaunotol (10, 25 or 50 mg/kg, orally, 3 h) significantly decreases the activity of myeloperoxidase (MPO) and the content of lipid peroxidase thiobarbituric acid reactive substance (TBARS) of gastric mucosa in male Wistar rats treated with C48/80^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male Wistar rats^[3]
Dosage:

10, 25 or 50 mg/kg
Administration:

Oral administration
Result:

Plaunotol attenuated the severity of the gastric mucosal lesions.

Chemical Information

CAS. Nr. 64218-02-6
Molecular Weight 306.48
Formel C₂₀H₃₄O₂
SMILES

C/C(C)=C\CC/C(C)=C/CC/C(CO)=C/CC/C(C)=C/CO
Synonyms

CS-684
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. S. Songkro, et al. Investigation of plaunoi-loaded micro/nanoemulsions for the treatment of dermatitis: formulation, evaluation and skin irritation studies. J. DRUG DEL. SCI. TECH. 2011 21 (5) 401-410.

[2]. Oshikawa N, et al. Plaunotol and geranylgeraniol induce caspase-mediated apoptosis in colon cancer. J Surg Res. 2009 May 15;153(2):246-53. [Content Brief]

[3]. Ohta Y, et al. Plaunotol prevents the progression of acute gastric mucosal lesions induced by compound 48/80, a mast cell degranulator, in rats. Pharmacology. 2005 Jul;74(4):182-92. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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