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Art. -Nr.: HY-139247

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pNPS-DHA

pNPS-DHA (Compound 19) is an orally active DHA-ethanolamide (DHEA) derivative that has antiallergic activity. pNPS-DHA inhibits IgE-dependent passive cutaneous anaphylaxis (PCA) reaction in mice. pNPS-DHA has anti-degranulating activity in RBL-2H3 mast cells with an IC₅₀ of 15 μM.

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CAS. Nr.: 2454246-25-2
Formel: C₂₈H₃₆N₂O₅S
Molecular Weight:512.66

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (260 KB)

pNPS-DHA Chemical Structure

CAS. Nr.: 2454246-25-2

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Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
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Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
RBL-2H3	IC₅₀	15 μM Compound: 59	Antiallergic activity in rat RBL2H3 cells assessed as inhibition of DNP-HSA-mediated degranulation by measuring decrease in beta-hexosaminidase activity preincubated for 30 mins followed by DNP-HSA stimulation and measured after 30 mins by 4-nitrophenyl 2 Antiallergic activity in rat RBL2H3 cells assessed as inhibition of DNP-HSA-mediated degranulation by measuring decrease in beta-hexosaminidase activity preincubated for 30 mins followed by DNP-HSA stimulation and measured after 30 mins by 4-nitrophenyl 2	[PMID: 31618024]
Sf9	IC₅₀	36 μM Compound: 59	Inhibition of human FAAH expressed in baculovirus infected Sf9 cells using N-(6-methoxypyridin-3-yl)octanamide as substrate measured for 15 mins by fluorescence based assay Inhibition of human FAAH expressed in baculovirus infected Sf9 cells using N-(6-methoxypyridin-3-yl)octanamide as substrate measured for 15 mins by fluorescence based assay	[PMID: 31618024]

Chemical Information

CAS. Nr. 2454246-25-2
Molecular Weight 512.66
Formel C₂₈H₃₆N₂O₅S
SMILES

CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(NS(=O)(C1=CC=C([N+]([O-])=O)C=C1)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (260 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Kim IH,et al. Structure-Activity Relationships of Fish Oil Derivatives with Antiallergic Activity in Vitro and in Vivo. J Med Chem. 2019 Nov 14;62(21):9576-9592. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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pNPS-DHA

Erucamide

Schisandrin

2-Linoleoyl glycerol

N-Oleoyl Taurine

Elocalcitol

Erucamide (Standard)

Schisandrin (Standard)

NAEPA

Heptadecanoyl ethanolamide

N-Arachidonoyl Taurine

N-Docosanoyl taurine

N-Lignoceroyl Taurine

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

pNPS-DHA

Erucamide

Schisandrin

2-Linoleoyl glycerol

N-Oleoyl Taurine

Elocalcitol

Erucamide (Standard)

Schisandrin (Standard)

NAEPA

Heptadecanoyl ethanolamide

N-Arachidonoyl Taurine

N-Docosanoyl taurine

N-Lignoceroyl Taurine

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

pNPS-DHA Related Classifications

HY-139247 Related Classifications