Propanedial (13.88 mM in water)
Based on 1 Customer Validation
Propanedial (Malondialdehyde) (13.88 mM in water) is one of the final products of lipid peroxidation. Propanedial causes protein inactivation, DNA damage and cross-linking by forming stable covalent adducts with biological macromolecules, which is the main mechanism for its cytotoxicity and genotoxicity. Propanedial production increases with the elevation of free radicals. Propanedial is a key biomarker for evaluating the level of cellular oxidative stress[1][2][3].
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- CAS. Nr.: 542-78-9
- Formel: C3H4O2
- Molecular Weight:72.06
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Speicherung:
Solution, -20°C, 1 year
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Biologische Aktivität
Propanedial can easily react with nucleophilic sites on biological macromolecules such as proteins and DNA (such as the ε-amino group of lysine), forming stable covalent adducts. The accumulation of excessive Propanedial and its adducts is an important aspect of the pathological processes of various aging-related diseases and mental disorders such as bipolar disorder[1][2][3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 542-78-9
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Appearance Liquid
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Molecular Weight 72.06
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Formel C3H4O2
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Color Colorless to light yellow
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SMILES
O=CCC=O
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Synonyms
Malondialdehyde
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Versand
Shipping with dry ice.
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Speicherung
Solution, -20°C, 1 year
Reinheit & Dokumentation
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Data Sheet (267 KB)
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SDS (394 KB)
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- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Ayala A, Muñoz MF, Argüelles S. Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. Oxid Med Cell Longev. 2014;2014:360438. [Content Brief]
[2]. Capuzzi E, Ossola P, Caldiroli A, Auxilia AM, Buoli M. Malondialdehyde as a candidate biomarker for bipolar disorder: A meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry. 2022 Mar 8;113:110469. [Content Brief]
[3]. Gaweł S, et al. Malondialdehyde (MDA) as a lipid peroxidation marker. Wiad Lek. 2004;57(9-10):453-5. Polish. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Propanedial (13.88 mM in water) Related Classifications
HY-141452 Related Classifications
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